红花黄色素对慢性肺原性心脏病急性加重期患者心功能及血小板功能的影响

Effects of Safflor Yellow on Cardiac Function and Platelet Function in Patients with Acute Exacerbation of Chronic Pulmonary Heart Disease

目的:观察红花黄色素对慢性肺原性心脏病(以下简称肺心病)急性加重期患者心功能及血小板功能的影响。方法:将72例慢性肺心病急性加重期患者随机分为红花黄色素治疗组与丹参注射液对照组;治疗组36例,在常规治疗的基础上加用红花黄色素,对照组36例予以常规治疗加用丹参注射液,两组均连续用药2周。治疗前后对心功能及血小板功能相关指标进行检测。结果:治疗组患者经红花黄色素治疗后左室射血分数明显增加(P<0.01),右室压、平均肺动脉压、血小板聚集率、血栓素B2水平均显著性下降(P<0.01或P<0.05),其心功能与血小板功能改善程度均优于对照组(P<0.01或P<0.05)。临床总有效率治疗组为97.2%,对照组为77.8%,治疗组疗效明显高于对照组(P<0.05);红花黄色素治疗期间未见严重不良反应。结论:红花黄色素能显著改善慢性肺心病急性加重期患者的心功能与血小板功能,是辅助治疗肺心病的一种安全有效药物。

Objective： To observe the effects of safflor yellow（ SY） on cardiac function and platelet function in patients with acute exacerbation of chronic pulmonary heart diseace（ CPHD）. Methods： Seventy two patients with acute exacerbation of CPHD were divided randomly into treatment group（ 36 cases） and control group（ 36cases）. The treatment group was treated with conventional medicines and SY,control group treated with conventional medicines and danshen injection,two groups were treated for 2 weeks. Cardiac function was assessed by pulsed Doppler echocardiography and purameters of platelet function were determined before and after treatment.Results： The left ventricle ejection fraction was increased（ P〈0. 01） and right ventricle pressure,average pulmonary artery pressure,platelet agglutinate rate and thromboxame B2（ TXB2） levels in SY group after treatment were significantly reduced（ P〈0. 01 or P〈0. 05respectively）,the improvement of cardiac function and platelet function were better than those in the control group（ P〈0. 01 or P〈0. 05 all）,the clinical total effective rates in treatment group was 97. 2%,it was better（ P〈0. 05） than that of control group（ 77. 8%）. No serious side-effects were found in SY group. Conclusion： SY can obviously improve cardiac function and platelet function in patients with acute exacerbation of CPHD,it is one of effective and safe drug for supportive treatment of CPHD.