NSE、CYFRA21-1、SCC联合检测在肺癌诊断中的应用

Application of Combined Detection of NSE, CYFRA21-1, SCC in the Diagnosis of Lung Cancer

目的探讨与分析神经元特异性烯醇化酶物(NSE)、细胞角蛋白19片段(CYFRA21-1)、鳞状细胞癌相关抗原(SCC)联合检测在肺癌诊断中的应用效果。方法将2011年8月至2013年8月于我院接受治疗且经病理诊断为肺癌的60例患者作为观察组,选取50例良性肺疾病患者作为对照1组,同时列入30例正常、健康人作为对照2组,选用发光法分别检测所有患者血清内NSE、CYFRA21-1及SCC水平,分析不同肿瘤标志物的敏感性及特异性。结果 1观察组患者血清内NSE、CYFRA21-1及SCC浓度水平明显高于正常值,且与对照1组、对照2组相比,差异具有明显统计学意义(F=21.871,P<0.05);2血清内NSE浓度水平检测以小细胞癌患者敏感度最高为75.00%,CYFRA21-1、SCC浓度水平检测则均以鳞癌患者敏感性最高,分别为44.45%、66.67%。单项肿瘤标志物浓度水平检测敏感性均<75.00%。选取三项联合检测以小细胞癌敏感度更高,为87.50%,联合检测与单项检测对比差异显著,P<0.05。结论临床上,为提高肺癌患者早期诊断的准确率,宜选用三项联合检测的方式,进而为肺癌患者的早期治疗提供指导,提升患者的生活质量。

Objective To explore and analyze the application efficacy of Neuron specific enolase matter （NSE）, cytokeratin 19 fragment （CYFRA21-1） and Squamous cell carcinoma antigen （SCC） in the diagnosis of lung cancer. Methods 60 cases had been pathological diagnosis as lung cancer in our hospital from August 2011 to August 2013 were selected as the observation group, 50 cases with benign pulmonary disease were selected as control lgroup, also, 30 cases of normal, healthy people were selected as control 2 group. All patients were respectively detected serum NSE, CYFRA21-1 and SCC levels by luminescence method respectively, analyze sensitivity and specificity of different tumor markers. Results ~ Serum NSE, CYFRA21-1 and SCC levels of the observation were significantly higher than the normal value, and compared with the control 1 group and control 2 group, there had significant statistical difference（F=21.871, P〈0.05）; @The concentration of serum NSE level detection in patients with small cell carcinoma had the highest sensitivity of 75%. CYFRA21-1 and SCC levels detection in patients with squamous cell carcinoma had the highest sensitivity, respectively were 44.45% and 66.67%. Single tumor marker detection sensitivity levels were lower than 75%. combined detection of three kinds of small cell carcinoma had higher sensitivity, 87.50%, combined detection and single detection had significantly difference, P〈0.05. Conclusion Clinically, in order to improve the accuracy of early diagnosis of patients with lung cancer, should use three kinds combined detection, provide guidance and early treatment for lung cancer patients, improve the quality of patients＇ life.