雄激素性脱发与代谢综合征关系的meta分析

Association between androgenetic alopecia and metabolic syndrome:a meta-analysis

目的：研究雄激素性脱发（AGA）与代谢综合征（MS）之间的关系.方法：检索国外PubMed、Web of Knowledge、Scopus数据库和Cochrance图书馆以及国内SinoMed、中国期刊全文数据库、万方和维普等数据库公开发表的有关AGA与MS之间关系的文献,选择符合入选标准的研究.采用StataSE 12.0软件对AGA与MS之间的关联实施meta分析.结果：四项病例—对照研究和两项横断面研究符合入选标准,共包含了4006例受试者.合并分析结果显示AGA与MS之间存在相关性（OR =2.70,95％ CI：1.67 -4.37,P＜0.01）.亚组分析显示：在男性（OR=2.30,95％ CI：1.33 -3.98,P＜0.01）和女性受试者（OR =4.61,95％CI：1.26 - 16.94,P＜0.05）中,以及欧洲（OR=5.29,95％ CI：2.86-9.80,P＜0.01）和亚洲地区受试者（OR=1.92,95％ CI：1.18 - 3.10,P＜0.01）中,AGA与MS均存在相关性.结论：根据现有资料,AGA与MS之间存在显著相关性,应对AGA患者中潜在的MS进行筛查.

Objective： To investigate the association between androgenetic alopecia （AGA） and metabolic syndrome （MS）. Methods： Literature on association between AGA and MS up to December Knowledge, Scopus, Cochrance 26, 2013 was searched from PubMed, Web of library, SinoMed, CNKI, Wanfang and VIP databases, and the studies met the eligibility criteria were se｜ected. Meta-analysis was performed by using StataSE 12.0 software to determine the association between AGA and MS. Results： Four case-control studies and 2 cross-sectional studies met the eligibility criteria, including 950 AGA subjects and 3056 control subjects were entered the analysis. Meta-analysis showed that AGA was significantly correlated with MS （OR = 2.70, 95% CI： 1.67- 4.37, P 〈 0.01 ）. Stratification analysis showed that AGA was significantly correlated with MS in male （ OR =2.30, 95% CI： 1.33-3.98, P 〈0.01 ） and female subjects （ OR = 4.61, 95% CI： 1.26-16.94, P 〈 O. 05 ） ; and AGA was significantly correlated with MS in European （ OR = 5.29, 95% CI： 2.86-9.80, P 〈 0.01） and Asian subjects （OR = 1. 92, 95% CI： 1. 18-3. 10, P 〈 0. 01）. Conclusion： Based on the available data, AGA may be a risk factor for MS, indicating that AGA patients would be a targeting population for screening of metabolic syndrome.