血清CgA在胃肠胰神经内分泌肿瘤临床诊断和疗效评价中的应用

Detection of serum chromogranin A for diagnosis and evaluation of prognosis of gastrointestinal and pancreatic neuroendocrine tumors

目的:探讨临床中血清嗜铬粒蛋白A(chromogranin A,CgA)在胃肠胰神经内分泌肿瘤临床诊断及临床疗效评估的应用价值.方法:选取青海大学附属医院肿瘤内科2010-01/2014-06的60例胃肠胰神经内分泌肿瘤患者为研究组,并选取同期我院健康体检的60名健康对象为对照组,测定两组血清CgA的表达状况.结果:研究组中血清CgA为98.4μg/L±12.7μg/L vs对照组45.6μg/L±9.67μg/L,P<0.05;血清CgA水平在性别、年龄、肿瘤功能状态、发生部位、分化程度和TNM分期中表达差异无统计学意义(P>0.05);远处转移与无远处转移患者血清CgA表达差异有统计学意义(P<0.05);研究组血清CgA为45.2μg/L±5.4μg/L vs治疗前98.4μg/L±12.7μg/L,P<0.05.结论:临床中对于胃肠胰神经内分泌肿瘤患者检测其血清CgA表达状况,对该病的诊断具有重要的意义.同时,对评价患者临床治疗也具有明显的作用.

AIM： To investigate the clinical value of serum chromogranin A（CgA） in the diagnosis and evaluation of prognosis of gastrointestinal and pancreatic neuroendocrine tumors.METHODS： Sixty patients with gastrointestinal and pancreatic endocrine tumors treated from January 2010 to June 2014 at our hospital（study group） and 60 healthy subjects（control group） were included in the study. Serum levels of CgA were detected in all the subjects. RESULTS： Serum CgA level was significantly higher in the study group than in the controlgroup（98.4 μg/L ± 12.7 μg/L vs 45.6 μg/L ± 9.67 μg/L, P 〈 0.05）. Serum CgA had no significant correlation with sex, age, tumor functional status, location, degree of differentiation or TNM stage（P 〉 0.05）, but was significantly correlated with distant metastasis（P 〈 0.05）. In the study group, posttreatment serum CgA was significantly lower than pretreatment value（45.2 μg/L ± 5.4 μg/L vs 98.4 μg/L ± 12.7 μg/L, P 〈 0.05）. CONCLUSION： Serum chromogranin A detection has important implications for the diagnosis and evaluation of the prognosis of gastrointestinal and pancreatic neuroendocrine tumors.