维生素D抗结直肠癌的研究进展

Advances in anti-cancer effect of vitamin D on colorectal cancer

结直肠癌是一种常见的恶性肿瘤,其发病机制涉及多个方面。目前流行病学及基础研究均支持,维生素D缺乏可能是导致结直肠癌的危险因素之一。进一步研究显示,维生素D与维生素D受体结合后可调节c-myc、抗凋亡因子B细胞性淋巴瘤-2(B cell lymphoma-2,Bcl-2)、表皮生长因子受体(epidermal growth factor receptor,EGFR)和血管内皮生长因子(vascular endothelial growth factor,VEGF)等与肿瘤分化、增殖、凋亡及血管形成相关的基因,从而发挥抗结直肠癌的作用。此外,维生素D还可通过调节Wnt、表皮生长因子(epidermal growth factor,EGF)和转化生长因子-β(transforming growth factor-β,TGF-β)等信号通路来拮抗结直肠癌。因此,本文将对维生素D抗结直肠癌相关的研究现况作一综述,以期为结直肠癌的防治提供一些新的线索。

Colorectal cancer is a kind of common malignant cancer,and its pathogenesis involves in several aspects.Recent epidemiological and experimental studies both support that vitamin D defi ciency may be a risk factor for colorectal cancer.Further research have shown that vitamin D binding to its receptor can inhibit the cancer by regulating many genes involved in tumor differentiation,cell proliferation,apoptosis,and vascular formation,such as c-myc,B cell lymphoma-2（Bcl-2）,epidermal growth factor receptor（EGFR） and vascular endothelial growth factor（VEGF）.Vitamin D can also inhibit the cancer by regulating several signalling pathways,such as Wnt,epidermal growth factor（EGF）,and transforming growth factor-beta（TGFbeta）.This article reviews the recent state of the studies related to vitamin D against colorectal cancer to provide some new clues for prevention and treatment of colorectal cancer.