淡斑美白精华液改善黄褐斑的临床观察

Clinical efficacy of the whitening essence for the treatment of melasma

目的:评估淡斑美白精华液改善黄褐斑的临床疗效及安全性。方法:采用双中心、随机、开放试验研究,将80例黄褐斑患者随机分为试验组(41例)和对照组(39例),分别于黄褐斑皮损处外用淡斑美白精华液及润白保湿乳,每天2次。在使用产品前以及使用后第2、4、8、12周评估黄褐斑皮损面积及严重程度指数(MASI)变化,皮肤色度仪定量测量皮肤颜色以及受试者自评。结果:在使用产品12周后,试验组和对照组的MASI下降率分别为55.44%和42.98%,属好转。治疗组有效率为95.1%,对照组为92.3%。两组疗效比较差异无统计学意义(P>0.05)。结论:淡斑美白精华液对黄褐斑有效,耐受性良好。

Objective： To evaluate the efficacy of the whitening essence （extracts of Chinese traditional medicine） for the treatment of melasma. Methods： A double-center, randomized and open clinical trial was conducted. Eighty patients with melasma were divided into 2 groups, the whitening essence was applied twice daily in the test group （41 cases）, while the control group （39 cases） was given moisturizing lotion twice daily. The changes of melasma area and severity index（MASI） score were assessed before and after treatment at weeks 0, 2, 4, 8 and 12. Skin color was quantitatively measured by skin colorimetel; and self-assessment of the patients was also analyzed. Results： The decrease of MASI score in the 2 groups were 55.44% （the test group） and 42.98% （the control group） after treatment of 12 weeks respectively, while the effective rates of the 2 groups were 95.1% and 92.3% respectively. The difference between the 2 groups was not statistically significant. Conclusion： The whiten- ing essence is safe and well tolerated for melasma.