摘要
Krüpple是果蝇分节基因"间隙基因"类的一个成员,它编码一个包含一个DNA结合序列的蛋白质,该序列由几个Cys2/His2型的锌指构成,一群与Krüpple的锌指结构高度同源的蛋白质被发现,命名为Krüpple样因子(Krüpple-like factor,KLFs),它们通过调控多种富含GC或CACCC的启动子的基因的表达,参与细胞增殖、分化、凋亡和肿瘤发生、发展等多种生理、病理过程。本文综述KLFs的结构、表达调控功能、主要家族成员及其在肿瘤研究中的现状,探讨其与肿瘤发生发展的关系。
Krtipple is a member of the ＂gap gene＂, flies segmentation gene, encoding a DNA binding sequence protein, the sequence is composed of several Cys2 / His2 type zinc finger. A group of highly homologous proteins with zinc finger structure of Krtipple were named as Krtipple sample factor （Krfipple-like factor, KLFs）. They are involved in cell proliferation, differentiation, apoptosis and tumor occurrence, development and a variety of physiological and pathological process through regulating the expressions of rich containing GC or CACCC promoter genes. This review explores its relationship with the occurrence and development of tumor.
出处
《解剖科学进展》
CAS
2014年第6期585-587,591,共4页
Progress of Anatomical Sciences
基金
沈阳市科技计划项目(F11-262-9-14)
