摘要
目的探讨膦甲酸钠氯化钠注射液治疗带状疱疹的疗效和安全性。方法回顾分析2007年1月-2013年1月在本科住院应用膦甲酸钠氯化钠注射液治疗带状疱疹的患者的病历资料,记录患者一般情况,症状体征和给药方式,以及疗效评价参数,包括:皮疹控制天数,皮疹大部好转天数,皮疹痊愈天数,疼痛开始缓解天数,疼痛大部消退天数,用药前和用药7d的疼痛程度视觉模拟评分(visual analogue scale,VAS)以及不良事件等。对数据进行统计学分析和分组比较。结果共采集病例205例,符合入组条件112例。疗效评价:平均皮疹控制天数2.3d,平均皮疹好转天数6.0d,平均皮疹痊愈天数10.6d。平均疼痛开始缓解天数2.8d,平均疼痛大部分消退天数8.7d。用药7d VAS平均改善56.53%,有效率93.14%。每日1次与2次给药组之间及男女性别组间疗效差异无统计学意义。低龄组疗效指标均优于高龄组。中低VAS组疗效指标均优于高VAS组。不良反应发生率3.57%,无严重不良反应。结论膦甲酸钠氯化钠注射液治疗带状疱疹有较好疗效,可以较快控制皮疹和改善疼痛症状。在优化给药方式前提下,膦甲酸钠氯化钠注射液治疗带状疱疹有较好的安全性。
Objective To investigate the efficacy and safety of foscarnet sodium and sodium chloride injection treatment of herpes zoster. Methods Retrospective analyzes the medical records of hospitalized patients of herpes zoster treated with foscarnet sodium and sodium chloride injection in our department from 2007 January to 2013 January. Collect patients' clinical data including the general condition, treatment, and efficacy evaluation parameters including the number of days of rash control, of rash improve, and of rash healing, the number of days of pain began to relieve, and of pain relieve significantly, the pain visual analog scale (VAS) score before treatment and the 7 days after treatment. The data were statistically analyzed and compared in groups. Results A total of 205 cases were collected, 112 cases entered the treatment groups. The mean days of rash control,of rash improve,and of rash healing were 2.3d,6.0d and 10.6d respectively. The a mean days of pain beginning,and of pain relief were 2.8d and 8.7d respectively. At the 7th day the average improvement of VAS was 56.53%, and total effective rate was 93.14%. There were no significant differences between once daily dosing group and twice daily dosing group, and sex groups. Efficacy evaluation index in younger age group were all superior to the aging groups, in the low VAS group were all superior to the high VAS group. The adverse reaction rate was 3.57%. No serious adverse reactions were observed. Conclusion Fos- carnet sodium and sodium chloride injection have a good effect for herpes zoster, and can quickly control the rash and improve the pain. Under the optimal administration,foscarnet sodium and sodium chloride injection has high safety in treatment of herpes zoster.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2014年第12期1238-1240,共3页
The Chinese Journal of Dermatovenereology
关键词
膦甲酸钠
带状疱疹
治疗
Foscarnet
Herpes zoster
Treatment