天津市孕妇孕期危险因素与儿童特应性皮炎关系的分析

Analysis of the Relationship between the Risk of Pregnancy Factors and Childhood Atopic Dermatitis in Tianjin

目的调查天津市儿童特应性皮炎(AD)的患病情况,探讨孕妇孕期各危险因素与儿童AD的关系。方法建立出生队列,通过问卷调查孕妇孕期家居及生活各因素,电话随访儿童AD的患病情况,对数据进行单因素及多因素分析。结果收回内容完整的调查问卷共1 208份,完成本次调查共计921份,诊断AD儿童35例,其中男19例,女16例,AD在2岁的患病率为3.80%。单因素分析父母过敏史、妊娠期服叶酸、居住情况(居住在城市或乡村)及家庭养宠物与儿童AD关系相关。在单因素分析的基础上筛选出有意义的变量进入多因素Logistic回归分析,父母过敏史可能为AD的危险因素。结论父母过敏史为AD的危险因素。

Objective To estimate the prevalence of childhood atopic dermatitis（AD） in Tianjin as well as its associated risk factors. Methods A birth cohort study was conducted. Questionnaires were performed by asking about the pregnant women general information and residential environment and the prevalence of AD. All children were followed up through telephone calls to know the prevalence of AD. The data were analyzed by univariate and multivariate logistic regressions. Results In this survey, 1 208 questionnaires were col- lected,of which 921 were valid. There were 35 AD patients（ 19 boys and 16 girls） in the total sample of 921 persons surveyed. The prevalence was 3.80% in 2 years old. By univariate logistic regression analyses, parental allergic history in pregnancy, folic acid supplemented,living conditions （urban or rural）, and the family pet were positively associated with childhood AD. By multivariate logistic regression analyses, parental allergic history was risk factors of childhood AD. Conclusion Parental allergic history may be the potential risk factors for childhood AD.