玻璃离子在牙本质再矿化中的作用

Glass ionomer function in dentin remineralization

玻璃离子因独特的自粘接性和释氟性能,在口腔领域应用广泛。用作充填材料时,玻璃离子释放的氟离子可预防继发龋、抑制釉质脱矿及促进再矿化。20世纪90年代,传统的牙体修复理念逐渐被口腔微创治疗所取代,原本需要去除的脱矿层得以保留,修复材料对脱矿牙本质的再矿化能力亦成为研究焦点之一。除玻璃离子所含氟离子的作用外,学者们还制备了酪蛋白磷酸肽-无定形磷酸钙、生物活性玻璃等改性玻璃离子材料,以观察其对牙本质的再矿化能力。初步的脱矿牙本质拟生再矿化试验已成功诱导出类似天然矿化胶原的纤维结构,而搭载拟生再矿化系统的玻璃离子修复体系尚处于探索阶段。本文就玻璃离子在牙本质再矿化中的作用作一综述。

Glass ionomer has been widely used in dental treatment for the past decades because of its self-adhesiveness and fluoride-releasing properties. Fluoride promotes mineralization and prevents secondary caries and enamel demineralization when applied as a restorative material. The concept of ＂minimal intervention dentistry＂ replaced the traditional idea of conservative dentistry in the 1990s. As a result, the demineralization zone is retained in the treatment of caries. Correspondingly, an increasing number of people started to focus on the capability of restorative material to remineralize the demineralized dentin. Accordingly, scholars have developed and detected the remineralization property of new materials, such as casein phosphopeptide-amorphous calcium phosphate and bioactive resin-modified glass ionomer, as a complement to the effects of fluoride.The structure of a mineralized collagen fiber similar to natural dentin has recently been introduced to primary in vitro biomimetic remineralization experiments on demineralized dentin. Meanwhile, the design of a glass ionomer restorative material system carrying a biomimetic remineralization property is ongoing. This review provides the details of glass ionomer function in dentin remineralization.