认知行为疗法联合氟西汀治疗儿童及青少年抑郁症的疗效

Curative effect of cognitive behavior therapy combined with fluoxetine in the treatment of children and adolescent depression

目的探讨认知行为疗法联合氟西汀治疗儿童及青少年抑郁症的疗效。方法 62例儿童及青少年抑郁症患者随机分为两组,单纯药物组30例给予口服抗抑郁药盐酸氟西汀,联合治疗组32例在接受药物治疗的同给给予认知行为治疗,于治疗前和治疗第4、8、12周采用24项版本汉密顿抑郁量表评估抑郁程度。结果两组汉密顿抑郁量表评分随着治疗时间增加逐渐下降,治疗前后比较差异有统计学意义(P<0.05),治疗第8、12周联合治疗组汉密顿抑郁量表评分明显低于单纯药物组(P<0.05),两组均未发生严重不良反应。结论认知行为疗法联合氟西汀治疗儿童及青少年抑郁症患者有较好的疗效,可以明显减轻患者的抑郁情绪。

Objective To explore the curative effect of cognitive behavior therapy combined with fluoxetine in the treatment of children and adolescent depression. Methods A total of 62 patients of child and adolescent depression were randomly divided into two groups. The simple drug group with 30 cases received oral administration of fluoxetine, and the combined treatment group with 32 cases received additional cognitive behavior therapy to drug treatment. The degree of depression was assessed by 24 items version of Hamilton depression scale before treatment and in the fourth, eighth, twelfth weeks in treatment. Results The Hamilton depression scale scores decreased along with the treatment time, and the difference between the score before and after treatment had statistical significance （P〈0.05）. In the eightfi and twelfth weeks in the treatment, the combined treatment group had remarkably lower Hamilton depression scale score than the simple drug group （P〈0.05）. No severe adverse reactions occurred inthe two groups. Conclusion The combination treatment by cognitive behavior therapy and fluoxetine has good curative effect in treating children and adolescent depression, and it can obviously relieve their depressive emotion.