细胞周期依赖性蛋白激酶8在宫颈癌及宫颈上皮内瘤变中的表达

Cyclin-dependent kinase 8 expression in human cervical carcinoma and cervical intraepithelial neoplasia

目的：探讨细胞周期依赖性蛋白激酶8（CDK8）在宫颈癌及宫颈上皮内瘤变中的表达意义。方法：收集2011年3月~2013年6月我院收治的56例宫颈癌患者,观察CDK8在宫颈癌不同病变组织、宫颈癌患者不同临床分期以及宫颈癌不同分化程度中的表达。结果：CDK8在正常组织、CINⅠ、CINⅡ、CINⅢ、宫颈癌中均有不同程度的表达,其阳性表达率分别为13.3%、55.6%、73.0%、90.0%、98.2%,各组阳性表达率进行比较差异有统计学意义（P〈0.05）;CDK8在临床Ⅰ期、Ⅱ期、Ⅲ期、IV期中具有不同的阳性表达率,其阳性表达率分别为68.8%、77.8%、83.3%、100.0%,各临床分期之间的阳性表达率进行比较差异有统计学意义（P〈0.05）;CDK8在宫颈癌不同分化程度中具有不同的阳性表达率,其中低分化、中分化以及高分化的阳性表达率分别为72.2%、87.5%、92.9%,不同宫颈癌分化程度的CDK8的阳性表达率进行比较差异有统计学意义（P〈0.05）。结论：CDK8的表达与宫颈癌的发生以及发展有着十分密切的关系,应用CDK8的表达去预测宫颈癌的病变以及转归具有十分重要的临床价值。

Objective：To investigate the cell cycle-dependent protein kinase 8expression in human cervical carcinoma and cervical intraepithelial neoplasia.Methods：A total of 56 cases of cervical cancer admitted from March 2011 to June 2013 in our hospital were selected,and CDK8 expression in different lesions at different clinical stages and the different degree of differentiation were determined and compared.Results：The positive expression rates of CDK8 in normal tissues,CINⅠ,CINⅡ,CINⅢ tissues were 13.3%,55.6%,73.0%,90.0,98.2%,and the difference was significant（P〈0.05）.The positive expression rates of CDK8 in clinical stageⅠ,Ⅱ period,Ⅲ period,Ⅳ period were 68.8%,77.8%,83.3% and 100.0%,respectively,and the difference was significant（P〈0.05）（P〈0.05）.The positive expression rates of CDK8 in poorly differentiated,medium differentiated,highly differentiated were 72.2%,87.5%,92.9%,with significant difference（P〈0.05）.Conclusion：CDK8expression has a very close relationship with occurrence and development of cervical cancer.It is valuable in predication of outcomes.