肾综合征出血热患者血清CRP、β_2-M的变化及意义

Change and significance of serum CRP and β_2-M in patients with hemorrhagic fever complicated with renal syndrome

目的:探讨肾综合征出血热(HFRS)患者血清C-反应蛋白(CRP)、β2-微球蛋白(β2-M)的变化及其临床意义。方法:选取本院收治的不同病期HFRS患者222例,采用胶乳法、放射免疫法分别检测患者血清中CRP、β2-M水平,并与正常健康人进行对比分析。结果:HFRS患者发热第2日CRP阳性率为83.3%,同期尿蛋白阳性率为33.3%;HFRS患者发热期、低血压期、少尿期CRP、β2-M均较正常人明显增高,差异具有统计学意义(P<0.05),多尿期、恢复期,逐渐下降并恢复正常。重危型患者CRP明显高于中型患者。血清β2-M在发热期、低血压期、少尿期、多尿期均高于正常人。结论:HFRS患者检测血清CRP、β2-M有助于的早期诊断,病情分析和预后判断。

Objective：To explore changes and clinical significance of serum CRP andβ2-M in the patients with hemorrhagic fever with renal syndrome（HFRS）.Methods：A total of 222 HFRS patients at different stages were included in our study.The latex assay and radioimmunoassay were used to detect the levels of serum CRP andβ2-M,respectively which were compared with those of the healthy individuals.Results：The CRP positive rate of the HFRS patients on the second day after suffering from fever was 83.3%,and the urine protein positive rate at the same stage was 33.3%.The levels of CRP andβ2-M in the HFRS patients at the pyretogenesis stage,hypotension stage,and oliguria stage were significantly higher than those in the healthy individuals（P〈0.05）,and the levels at the diuretic stage and recovery stage were gradually declined and returned to be normal.The CRP level in the critical ill patients was obviously higher than that in the moderate ill patients.The serumβ2-M levels at the pyretogenesis stage,hypotension stage,oliguria stage and diuretic stage were all higher than that in the healthy individuals.Conclusions：It can be concluded that the detection of serum CRP andβ2-M in the HFRS patients can be conducive to the early diagnosis,condition analysis,and prognosis.