盐酸氨溴索联合肺表面活性物质治疗新生儿呼吸窘迫综合征的疗效观察

Curative effect of ambroxol hydrochloride combined with pulmonary surfactant in treatment of neonatal respiratory distress syndrome

目的:观察盐酸氨溴索联合肺表面活性物质(PS)治疗新生儿呼吸窘迫综合征(NRDS)的临床疗效。方法:将135例NRDS患儿随机分为3组,A组(n=45)单纯给予盐酸氨溴索治疗,B组(n=45)单纯给予PS治疗,C组(n=45)采用盐酸氨溴索+PS联合治疗;对比3组的临床效果。结果:A组和B组的治愈率和死亡率比较,差异无统计学意义(P>0.05);C组的治愈率和死亡率均高于A组和B组,差异具有统计学意义(P<0.05)。结论:盐酸氨溴索联合PS治疗NRDS的临床疗效确切,可以迅速改善缺氧症状,减少机械通气和氧疗时间,改善预后。

Objective：To observe the clinical curative effects of ambroxol hydrochloride combined with pulmonary surfactant（PS）in treatment of neonatal respiratory distress syndrome（NRDS）.Methods：135patients with NRDS were randomly divided into 3groups,group A（n=45）only received ambroxol hydrochloride treatment,B group（n=45）treated only with PS treatment,group C（n=45）＋PS with ambroxol hydrochloride combined therapy.Clinical effects of 3groups were compared.Results：The cure rate and mortality rate of group A and group B were not significantly different（P〉0.05）,the cure rate and the mortality rate of group C were higher than those in group A and group B（P〈0.05）.Conclusion：The clinical efficacy of ambroxol hydrochloride combined with PS in the treatment of NRDS is accurate,it can rapidly improve the symptoms of hypoxia,reduce mechanical ventilation and oxygen therapy,improve the prognosis.