腹腔镜手术与开腹手术对直肠癌患者术后血清学指标的影响

Effects of laparoscopic and open operation on serum index of rectal cancer patients

目的:分析腹腔镜与开腹手术对直肠癌患者术后血清学指标的影响。方法:选择在本院接受手术治疗的直肠癌患者作为研究对象,随机分为接受开放手术治疗的对照组和接受腹腔镜手术治疗的观察组,比较两组的氧化应激反应、肿瘤恶性生物学行为、细胞免疫功能。结果:(1)氧化应激指标:观察组的皮质醇(Cor)、肾上腺素(E)、还原型谷胱甘肽(GSH)、超氧化物歧化酶(SOD)水平低于对照组,差异有统计学意义(P<0.05);(2)肿瘤恶性生物学行为:观察组血清的血管内皮生长因子(VEGF)、酸性成纤维生长因子(aFGF)、碱性成纤维生长因子(bFGF)水平均低于对照组,差异有统计学意义(P<0.05);(3)细胞免疫功能:观察组的肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)水平低于对照组,白细胞介素-6(IL-6)、白细胞介素-10(IL-10)水平高于对照组,差异有统计学意义(P<0.05)。结论 :腹腔镜手术有助于缓解氧化应激反应、抑制肿瘤恶性生物学行为、提高细胞免疫功能,是治疗直肠癌的理想手术方法。

Objective：To study the effects of laparoscopic and open operation on serum index of rectal cancer patients.Methods：Rectal cancer patients were enrolled and randomly divided into observation group which were scheduled for laparoscopic operation and control group that were scheduled for open operation.Then oidative stress,tumor malignant biological behavior,cell immune function were compared.Results：（1）Oidative stress：Cor,E,GSH,SOD contents of observation group were lower than those of control group;（2）tumor malignant biological behavior：VEGF,aFGF,bFGF contents of observation group were lower than those of control group;（3）cell immune function：TNF-α,IFN-γcontents of of observation group were lower than those of control group;IL-6,IL-10 contents of observation group were higher than those of control group.Conclusion：Laparoscopic operation is helpful to relieve oidative stress,suppress tumor malignant biological behavior,improve cell immune function;it’s an ideal operation method in treating rectal cancer.