核不均一性核糖核蛋白的异常表达与肿瘤发生

Correlation between abnormal heterogeneous nuclear ribonucleoprotein expression and tumors

核不均一性核糖核蛋白(heterogeneous nuclear ribonucleoprotein,hn RNP)家族是一组调节前体m RNA(pre-m RNA)分子的选择性剪接以及m RNA转运、翻译和稳定性等的多功能RNA结合蛋白。hn RNP A1和hn RNP A2是该家族中表达水平最高、研究最为广泛的成员,两者具有高度的序列同源型和功能相似性,在多种肿瘤组织中高表达,通过调节多种肿瘤相关基因pre-m RNA选择性剪接和m RNA稳定性,参与调控了肿瘤细胞的增殖、凋亡、肿瘤相关的炎症与免疫反应、上皮-间质转换等多种细胞生物学过程,从而成为肿瘤发病分子机制以及肿瘤诊断和治疗领域研究的热点。

Heterogeneous nuclear ribonucleoprotein （hnRNP） is a family of multifunctional nuclear RNA-binding proteins that regulate the alternative splicing of pre-mRNA and the transport, translation, and stability of mRNA. The most abundant and best charac- terized proteins of this group are hnRNP A 1 and hnRNP A2, which share a high degree of sequence homology and functional similarity. HnRNP A1 and hnRNP A2 are upregulated in multiple human tumors and modulate the alternative splicing and mRNA stability of vari- ous tumor-related genes critical to tumor cell growth, apoptosis, inflammatory and immune reactions, and epithelial-to-mesenchymal transition. Therefore, hnRNP A 1 and hnRNP A2 have potential diagnostic,promaostic, and therapeutic values.