经尿道前列腺等离子双极电切术联合内分泌治疗晚期前列腺癌合并膀胱出口梗阻疗效观察

Curative effect observation of TUPKVP combined with endocrine therapy for advanced prostate cancer with bladder outlet obstruction

目的：观察经尿道前列腺等离子双极电切术联合内分泌治疗晚期前列腺癌合并膀胱出口梗阻患者的疗效。方法选择2008年3月至2013年3月10例确诊为晚期前列腺癌合并膀胱出口梗阻患者，行经尿道前列腺等离子双极电切术联合内分泌治疗。结果10例患者均一次性手术成功，术后随访8~68个月，其中5例患者死亡，5年生存率为50%，所有患者术后 IPSS 评分、QOL 评分、剩余尿量、最大尿流率及 PSA 均较术前明显改善，差异有统计学意义（P 〈0.01）。结论经尿道前列腺等离子双极电切术联合内分泌治疗晚期前列腺癌合并膀胱出口梗阻，可有效解决尿路梗阻，延缓前列腺癌的进展，提高生活质量，临床效果满意。

Objective To observe the effect of transurethral plasmakinetic resection of prostate （TUPKVP）combined with endocrine therapy on advanced prostate cancer with bladder outlet obstruc-tion. Methods Ten patients diagnosed with advanced prostate cancer with bladder outlet obstruction were treated by TUPKVP combined with endocrine therapy from March 2008 to March 2013. Results Ten patients were successful in operation. Postoperative follow-up of 8 - 68 months,with 5 patients died, the 5 - year survival rate was 50% . IPSS,QOL,postvoid residual volune,Qmax and PSA improved signif-icantly（P 〈 0. 01）. Conclusions TUPKVP combined with endocrine therapy can relive the bladder out-let obstruction symptoms and delay the progress of prostate cancer in patients with advanced prostatic cancer,and improve the quality of the patients’life,the clinical effect is satisfactory.