实时动态胰岛素泵对1型糖尿病血糖调节的有效性研究

The efficacy of sensor-augmented insulin-pump in regulating the blood glucose of type 1 diabets

目的观察实时动态胰岛素泵对1型糖尿病(T1DM)平均血糖及血糖波动控制的有效性。方法将30例T1DM患者随机分为3C组和CSII组,每组15例。3C组接受持续皮下胰岛素输注(CSII)、实时动态血糖监测(RT-CGMS)和Care Link软件治疗;CSII组接受CSII和指尖血糖监测治疗。两组均佩戴CGMS 3 d,比较3 d平均血糖(MBG)、血糖的标准差(SDBG)、日内平均血糖波动幅度(MAGE)和血糖小于3.9 mmol/L的曲线下面积(AUC3.9)变化情况。结果第1天两组MBG、SDBG、MAGE、AUC3.9差异无统计学意义。第2、3天3C组MBG、SDBG、MAGE、AUC3.9显著低于CSII组,差异均有统计学意义(P<0.05)。结论 3C治疗可以更好地降低T1DM平均血糖,减少血糖波动及低血糖发生。

Objective To understand the effect of sensor-augmented insulin pump（SAP） use on mean glucose concentration and blood glucose fluctuations of type 1 diabetes mellitus. Methods 30 type 1 diabetes mellitus were randomly assigned to 2groups of treatment with SAP, continuous subcutaneous insulin infusion（CSII） therapy.Indicators of further observation included mean glucose concentration（MBG）, standard deviation of BG（SDBG）, mean amplitude of glycemic excursions（MAGE）, Area under curve 3.9（AUC3.9）. Results No significant differences were observed among the two groups in terms of the MBG, SDBG, MAGE, or AUC3.9 at the beginning of treatment. By short-term elaborate regulations, the MBG, SDBG,MAGE, and AUC3.9 of the SAP group were better than those of the CSII group（P0.05）. Conclusion SAP therapy was able to lower mean blood glucose, reduce blood glucose fluctuations,and reduce hypoglycemia.