苦碟子注射剂对慢性阻塞性肺疾病急性加重患者血清脂联素、白细胞介素-1β和白细胞介素-6水平的影响

Effects of Ixeri Sonhifolia injection on the levels of serum adiponectin,IL-1β and IL-6 in acute exacerbated chronic obstructive pulmonary disease patients

目的研究苦碟子注射剂对慢性阻塞性肺疾病急性加重(AECOPD)患者血清脂联素(APN)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)水平的影响,从气道炎症和与细胞炎症因子关系的角度探讨苦碟子注射剂治疗AECOPD的可能作用机制。方法将60例AECOPD患者按随机数字表法分为治疗组(30例)与对照组(30例)。对照组予常规治疗,治疗组在常规治疗基础上加用苦碟子注射剂40 m L,iv gtt,qd,疗程为14 d。2组均在治疗前后检测血清APN、IL-1β、IL-6、动脉氧分压[p(O2)]、动脉二氧化碳分压[p(CO2)]、纤维蛋白原定量(FBG)、D-二聚体定量(DD)等指标,并与30名健康体检者的血清APN、IL-1β、IL-6结果进行对照。结果治疗前2组患者血清ANP、IL-6、IL-1β、p(O2)、p(CO2)、FBG、DD及CCQ评分值之间差异均无统计学意义(P>0.05),但血清IL-6、IL-1β水平明显高于健康对照组(P<0.01),而APN水平显著低于健康对照组(P<0.01);治疗后2组患者血清APN、IL-6、IL-1β、p(O2)、p(CO2)、FBG、DD及CCQ评分值与治疗前比较差异均有统计学意义(P<0.01或P<0.05),且治疗组与对照组之间比较差异也有统计学意义(P<0.01或P<0.05)。结论苦碟子注射剂可以改善AECOPD患者的临床症状,并降低血清IL-1β、IL-6及升高APN水平,其作用机制可能与其通过调节上述炎症因子的表达而发挥降低气道炎症反应作用有关。

AIM To explore the action mechanism of Ixeri Sonhifolia injection by investigating the effect of medicine on the levels of serum adiponectin（APN）, IL-1β and IL-6 in acute exacerbated chronic obstructive pulmonary disease（AECOPD） patients. METHODS Sixty patients with AECOPD were randomly assigned to the treatment group and the control group. Routine therapies for COPD were given to patients in the control group, while 40 mL Ixeri Sonhifo- lia injection was given to those in the treatment group based on routine therapies by intravenous dripping, once daily for total 14 d. The levels of APN, IL-1β and IL-6 were evaluated before treatment and after treatment. The levels of the cy- tokins were compared with 30 healthy controls. RESULTS There were no significant differences in the value of APN, IL- 1β, IL-6, p （ O2 ）, p （ CO2）, FBG, DD and CCQ scores before treatment between 2 groups （ P 〉 0.05 ）. Before treat- ment, the levels of serum of IL-6, IL-1βin control group and treatment group were higher than those in health control group （P 〈 0.01 ） . The levels of serum of APN in 2 groups were lower than those in health control group. After treat- ment, there were significant differences in the level of serum of IL-6, IL- 1β, p （ O2）, p （ CO2）, FBG, DD and CCQ scores between 2 groups （ P 〈 0.01, P 〈 0.05）. In comparison between 2 groups after treatment, every index obove in treatment group was improved much significantly （ P 〈 0. 01, P 〈 0. 05）. CONCLUSION Ixeri Sonhifolia injection can reduce the levels of IL-6, IL-1β and improve the clinical symptoms and the levels of APN in AECOPD patients. The mechanisms may through certain anti-inflammatory effects to improve clinical efficacy of AECOPD patients.