血压晨峰对靶器官损害的研究进展

Research advances of effect of morning blood pressure surge on target organ damage

血压晨峰(morning blood pressure surge,MBPS)作为高血压的一项指标,近年来,国内外大量研究业已证实其作为心脑血管事件如脑卒中、心肌梗死、心绞痛、恶性心律失常等的危险因素,独立于平均压,可加速心、脑、肾、动脉血管等靶器官的损害,加大了心脑血管事件的发生率。通过中国知网、维普、万方、Pub Med等数据库,笔者检索了2003至2013年,有关MBPS的临床随机对照试验研究及队列研究,现对MBPS的定义、分类、对靶器官的损害等问题进行综述。

In recent years, morning blood pressure surge （MBPS） has been taken as an indicator of hypertension. At home and abroad, a number of studies have confirmed that the MBPS is one of the risk factors of cardiovascular events such as stroke,myocardial in- farction, angina pectoris, malignant arrhythmia,which independent of average systolic and diastolic pressure. MBPS can accelerate the heart, brain, kidney, arteries and other target organ damage, and can also increase the incidence of cardiovascular events. By searching the database of CNKI,VIP,Wan Fang,PubMed etc,the author included the clinical trials of MBPS from 2003 to 2013 and discussed on the definition and classification of MBPS and the relationship between MBPS and target organ damage.