PDGF、IL-11在男性强直性脊柱炎骨代谢中的作用研究

Role of IL-11,PDGF in Bone Metabolism of Male Patients with Ankylosing Spondylitis

目的研究AS患者骨质疏松(OP)情况及血小板衍生生长因子(PDGF)、白细胞介素-11(IL-11)在男性AS骨代谢中的作用。方法 AS患者不同部位骨密度(BMD)应用双能X线吸收法(DXA)测定,AS患者及对照组血清PDGF、IL-11水平采用ELISA法检测,并与不同部位BMD及临床指标之间进行相关性分析。结果在30例AS患者中OP发生率为36.67%,AS患者血清IL-11水平(112±89ng/L)显著低于正常对照组,PDGF水平(44272±7078ng/L)显著高于正常对照组。AS患者PDGF与股骨颈、大转子骨密度、血小板计数(PLT)呈正相关(P<0.05),与血清磷(P)呈负相关(P<0.05)。IL-11与腰椎BMD呈负相关(P<0.05)。结论 AS患者OP发生率较高,其继发OP与炎性相关的骨代谢异常有关,多因素共同参与了AS骨代谢的调节。

Objective To investigate the incidence of osteoporosis （OP） and the role of PDGF、IL-11 in bone metabolism of male patients with ankylosing spondylitis.Methods Bone mineral density （BMD） of AS patients was measured through dual-energy X-ray absorptiometry （DXA）.Serum levels of interleukin-11 （IL-11） and platelet-derived growth factor （PDGF） were detected by enzyme linked immunosorbent assay（ELISA）,and compared with normal controls.Results The incidence of OP in AS patients was 36.67％.Compared with normal controls,the levels of serum IL-11 in AS patients（112 ± 89ng/L）were significantly lower,and the levels of serum PDGF（44272 ± 7078ng/L）were significantly higher.The level of serum PDGF was positively correlated with the BMD of femoral neck,the BMD of greater trochanter and the level of PLT（P ＜ 0.05）,but it was negatively correlated with the level of serum P（P ＜ 0.05）.The level of IL-11 was negatively correlated with the BMD of lumbar（P ＜ 0.05）.Conclusion There was higher incidence of OP in AS patients,which was related with the abnormality of bone metabolism induced by inflammation.Multiple factors participated in the regulation of bone metabolism of AS.