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细胞质膜及内膜酸化作用的调控及意义 被引量：1

Regulation and significance of acidification of plasma membrane and intracellular membranes
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摘要 真核细胞内细胞器的酸性环境是内吞作用、溶酶体酶分泌等生理活动的重要条件,液泡三磷酸腺苷酶(vacuolar ATPases,V-ATP)和氯离子通道(chloride channel,CLC)家族在真核细胞内各种膜性结构及质膜上广泛分布,它们参与和调节囊泡内的酸化作用,文章对V-ATP酶和CLC蛋白的分布、结构、作用机制及生理病理意义作一综述。 Acidic environment of organelles of eukaryotic cells plays an important role in endocytosis, the secretion of lysoso-mal enzymes and other physiological activities.V-ATPase （vacuolar ATPases） and CLC （chloride channel） family are widely distribu-ted and present in virtually all eukaryotic cells in intracellular membranes and in the plasma membrane.They are responsible for the a-cidification of the vesicular interior.In this paper, the distribution, structure, mechanism of action and physiological and pathological significance of V-ATPase and CLC protein are discussed.
作者 胡海滢 刘伟敬 刘华锋
机构地区 广东医学院附属医院肾病研究所
出处 《医学研究生学报》 CAS 北大核心 2014年第11期1223-1225,共3页 Journal of Medical Postgraduates
基金 国家自然科学基金(81270798)
关键词 液泡三磷酸腺苷酶 氯离子通道 酸化作用 Vacuolar ATPases Chloride channel Acidification
分类号 R36 [医药卫生—病理学]
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参考文献27

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二级参考文献97

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医学研究生学报
2014年 第11期

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