新疆胃食管反流病患者食管外表现的发生率及危险因素的研究

Incidence and risk factors of extra-esophageal manifestations in gastroesophageal reflux disease patients in Xinjiang

目的探讨新疆胃食管反流病(gastroesophageal reflux disease,GERD)患者食管外表现的发生率及危险因素。方法回顾性分析新疆GERD患者中不同性别和不同民族3种常见的食管外表现的发生率及相关性,并通过单因素和多因素分析新疆GERD患者发生食管外表现的危险因素。结果新疆GERD患者3种食管外表现的总发生率、反流性咽喉炎、反流性咳嗽和反流性哮喘的发生率分别为47.01%、27.24%、15.67%和12.31%,三者之间无相关性;男性与女性患者3种食管外表现的总发生率、反流性咽喉炎、反流性咳嗽和反流性哮喘的发生率之间的差异均无统计学意义(P>0.05)。汉族患者3种食管外表现总发生率、反流性咳嗽和反流性哮喘的发生率均低于维吾尔族,但汉族患者反流性咽喉炎的发生率高于维吾尔族。危险因素分析的结果显示:维吾尔族、劳累、吸烟、进食过饱、饮食结构、辛辣饮食和高Gerd Q量表评分是新疆GERD患者发生食管外表现的独立危险因素。结论新疆GERD患者3种食管外表现的发生之间无相关性;新疆维吾尔族GERD患者3种食管外表现的总发生率及单个发生率均不同于汉族;民族为维吾尔族、劳累、吸烟、进食过饱、饮食结构以肉食为主、辛辣饮食和高Gerd Q量表评分可以增加新疆GERD患者食管外表现的发生率。

Objective To investigate the incidence and risk factors of extra-esophageal manifestations of gastroesophageal reflux disease （GERD） in Xinjiang.Methods The incidences and relevance of three kinds of extra-esophageal manifestations were analyzed retrospectively.The risk factors for the incidence of extra-esophageal manifestations were analyzed by univariate and multivariate analysis.Results The total incidence of the three kinds of extra-esophageal manifestations was 47.01％.The incidences of reflux laryngopharyngitis,cough and asthma were 27.24％,15.67％and 12.31％,respectively,and there was no correlation among them.The total and individual incidences of the three kinds of extra-esophageal manifestations were not statistically different between the male and female.The total and individual incidences of reflux cough and asthma were lower in Han than Uygur,but the incidence of reflux laryngopharyngitis was higher in Han than Uygur.Risk factors anlysis showed that Uygur,exertion,smoking,fed-upness,diet structure,acrimonious diet,and high GerdQ scores were risk factors of extra-esophageal manifestations of GERD.Conclusion There is no correlation among the incidences of the three kinds extra-esophageal manifestations of GERD patients in Xinjiang.The total and individual incidences of the three kinds of extra-esophageal manifestations are different between Han and Uygur.Uygur,exertion,smoking,fed-upness,diet structure,acrimonious diet,and high GerdQ scores could increase the incidence of extra-esophageal manifestations in GERD patients in Xinjiang.