二陈汤加减影响睡眠期上气道-食管压力研究

Study on the Influence of the Modified Erchen Decoction on Upper Airway-Esophagus Pressure During the Stage of Sleep

目的通过二陈汤加减对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者进行系统治疗,观察患者治疗前后上气道-食管各阻塞平面最低压力、体重指数、LSaO2、AHI、证候评分这几项数值的变化,判断中药方剂对OSAHS的疗效。方法对53例中、重度OSAHS患者进行整夜睡眠呼吸监测和同步上气道压力测定,根据有无中医治疗意愿分为治疗组及对照组。治疗组以二陈汤加减,对照组作减肥等生活调理,疗程3个月。复查PSG及同步上气道压力测定,2组数据分别作治疗前后对比。结果二陈汤加减治疗后P1及P2点压力波动减少,有显著差别;LSaO2及AHI有差别,BMI无差别。结论二陈汤加减治疗OSAHS患者,对其睡眠期上气道阻塞平面负压有减轻作用,对LSaO2及AHI两指标也有缓解作用,对体重指数无效。

Objective To investigate the dynamic changes in the upper airway that cause the obstructive sleep apnea-hypopnea syndrome by measuring the variations of upper airway pressures in the treatment of Erchen Decoction. Methods 53 patients with OSAHS examined polysomnography with upper airway pressure at the same time. divided into 2 groups, the treatment group was treated with Erchen Decoction, the control group was treated normally such as weight loss, each group treated for 3 months, reexamined polysomnography and upper airway pressure, contrasted the data of before-and-after. Results The negative pressure fluctuations of P1 and P2 decreased, there are significant difference between before-and-after. Conclusion With treatment of Erchen Decoction, the upper airway negative pressure of obstruction reduced, and then eased the data of LSaO2 and AHI, it’s invalid to the data of BMI for treatment group.