苦荞全叶及其醇提物对高脂血症仓鼠血脂的影响

Effect of Tartay Buckwheat Leaves and Alcohol Extract on Blood Lipid in Hyperlipemia Hamsters

研究生长时间为55d^75d苦荞全叶及其醇提物对高脂血症仓鼠血脂调节作用。雄性仓鼠适应环境1周后,随机分为5组(n=8),分别为空白组、模型组、苦荞全叶组和苦荞叶醇提物低、高剂量组。饲喂6周后眼底静脉丛取血,断颈处死,测定血清与肝脏中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和丙二醛(MDA)等各项指标。与模型对照组相比,苦荞全叶及其醇提物各剂量组血清、肝脏和粪便中TC、TG含量均极显著降低(P<0.01),血清中HDL-C极显著增高,动脉粥样硬化指数(AI)极显著降低(P<0.01),血清和肝脏中的MDA含量均极显著降低(P<0.01)。苦荞全叶及其醇提物对高脂血症仓鼠具有降血脂的作用。

This study was conducted to investigate the effects of tartay buckwheat leaves and its alcohol extracts on hypolipidemic hamsters. Male hamsters were randomly divided into six groups （n=8）：normal group, model group, low-dose and high-dose groups of tartay buckwheat leaves alcohol extracts and tartay buckwheat leaves group. After feeding 6 weeks, hyperlipidemia indicators were tested. Compared with the model group, the total cholesterol （TC） and triglyceride concentrations （TG） , atherogenic index of serum and liver were significantly decreased by feeding the tartay buckwheat leaves and alcohol extracts; the concentration of high density lipoprotein cholesterol in serum exhibited a significantly increase. Meanwhile , the content of MDA was decreased in serum and liver. The results suggested that the tartay buckwheat leaves and alcohol extracts had hypolipidemic activity.