老年慢性阻塞性肺疾病合并糖尿病患者免疫功能变化及临床意义

Changes and Significance of Immune Function in Old Patients with Chronic Obstructive Pulmonary Disease Complicated by Diabetes Mellitus

【目的】研究老年慢性阻塞性肺疾病（COPD）合并糖尿病（DM）的患者免疫功能变化及临床意义。【方法165例年龄大于65岁的老年COPD稳定期患者分为COPD合并DM组（35例）和COPD组（30例），同时选择20例健康老年人作为对照组，分别测定外周血细胞免疫和体液免疫指标。【结果】COPD＋DM组IgA、IgG、IgM、CD4＋水平均低于COPD组和对照组，CD8＋水平高于COPD组和对照组，CD4＋／CD8＋倒置更为明显，差异均有统计学意义（P〈0．05），而CD3＋水平cOPD组和COPD＋DM组之间无显著性差异（P〉0．05）。【结论】老年COPD合并DM的患者免疫功能低下，预防和控制DM对于提高COPD患者的免疫功能有重要意义。

[Objective] To explore the changes and significance of immune function in old patients with chronic obstructive pulmonary disease（COPD） complicated by diabetes mellitus （DM）. [Methods] A total of 65 old patients （aged more than 65 years old） with stable COPD were divided into COPD with DM group（ n =35） and COPD group（ n = 30）. Meanwhile, 20 healthy old people were chosen as the control group. Cellular immunity and humoral immunity indexes in peripheral blood were measured, [Results] IgA, IgG, IgM and CD4＋ levels in COPD with DM group were lower than those in COPD group and control group, while CD8＋ level was higher than that in COPE） group and control group, and the inversion of CD4＋/CD8＋ was more obvious, and there were significant differences（ P 〈0.05）. There was no significant difference in CD3＋ between COPD group and COPD with DM group（ P〉0.05）. [Conclusion] Elderly patients with COPD complicated by DM have immune dysfunction. The prevention and control of DM is important for improving the immune function in patients with COPD.