复方斑蝥胶囊联合 CHOP 化疗治疗恶性淋巴瘤疗效观察

Observation on Clinical Efficacy of Compound Cantharidin Capsule Combined with CHOP Chemo-therapy for the Treatment of Malignant Lymphoma

【目的】探讨复方斑蝥胶囊联合CHOP方案化疗对恶性淋巴瘤患者的临床近期疗效。【方法】本院收治的97例恶性淋巴瘤患者，分为对照组（ n＝51）及观察组（ n ＝46）。对照组单用CHOP方案化疗，观察组在CHOP方案基础上加用复方斑蝥胶囊（一次3粒，每天2次口服）。21 d后重复化疗；疗程结束后进行疗效评定。【结果】观察组总有效率为78．26％（36／46）；对照组总有效率为64．70％（33／51）；观察组总有效率显著高于对照组，且两组相比较差异有显著性（ P ＜0．05）；K PS评分改善率分别是86．96％和66．67％％，且两组相比较差异有显著性（ P ＜0．05）；观察组中不良反应低于对照组，且两组相比较差异有显著性（ P ＜0．05）。【结论】复方斑蝥胶囊联合CHOP化疗治疗恶性淋巴瘤的临床近期疗效显著，不良反应低，值得临床推广应用。

[Objective]To explore the short‐term efficacy of compound cantharidin capsule combined with CHOP chemotherapy for the treatment of patients with malignant lymphoma .[Methods]Totally 97 patients with malignant lymphoma in our hospital were divided into control group（ n=51） and observation group（ n=46） .The control group received CHOP regimen ,while the observation group received CHOP regimen combined with oral compound cantharidin capsule（3 capsules once ,twice daily） .Chemotherapy was repeated after 21 days .The effi‐cacy was evaluated after treatment .[Results]The total effective rate in observation group was 78 .26% （36/46） which was markedly higher than that in control group（64 .70% ,33/51） ,and there was significant difference（ P〈0 .05） .The improvement rate of KPS in observation group and control group was 86 .96% and 66 .67% respective‐ly ,and there was significant difference（ P 〈0 .05） .The incidence of adverse reaction in observation group was lower than that in control group ,and there was significant difference（ P〈0 .05） .[Conclusion]Compound canthar‐idin capsule combined with chemotherapy for the treatment of malignant lymphoma has significant short‐term effi‐cacy .Therefore ,it is worthy of clinical promotion .