摘要
目的:本研究评价中医药综合方案治疗根治术后小肝癌的疗效。方法:对2005年1月—2008年12月在广西医科大学第一附属医院行根治术的小肝癌患者161例纳入回顾性队列分析,其中53例接受中医药综合方案治疗(TCM组),80例接受介入疗法(TACE组),20例接受中医药和介入疗法(TCM-IT组),8例单纯手术治疗(SO),以无病生存期(DFS)和总生存期(OS)为观察指标,Kaplan-Meier方法统计分析各组总生存率和无病生存率。结果:共纳入161例小肝癌患者,12例失访,失访率7.45%,其中TCM组第1年、2年、3年总生存率分别为91.5%、84.8%、84.8%;介入组1年、2年,3年总生存率分别为91%、85.5%、60.5%,有明显统计学差异(P=0.008);TCM与介入联合组和单纯手术组中位生存期分别是30.667个月和29.267个月。TCM组1年、2年的无病生存率分别为84.5%、81.7%,介入组1年、2年的无病生存率为83.9%、76.5%,无统计学差异(P=0.461)。结论:中医药综合治疗方案与TACE介入治疗术相比,在提高根治术后小肝癌患者的生存率方面具有优势,其结果有待于进一步前瞻性随机对照研究验证。
Objective : To investigate the therapeutic effects of a comprehensive individualized treatment program using TCM for small hepatocellular carcinoma after resection. Methods: In this trial, a total of 161 patients who stayed in First Affiliated Hospital of Guangxi Medical University were enrolled from January 2005 to December 2008. 53 patients were treated with a TCM-only ( TCM ) group. 80 patients were treated with an transarterial ehemoembolization-only ( TACE ) group. 20 patients were treated with a TCM combined with interventional therapy ( TCM-IT ) group. 8 patients were treated with patients were treated with a simple operation ( SO ) group. Disease free survival ( DFS ) and overall survival ( OS ) were the observation indexes. Prognostic factors were correlated with OS rates and ( DFS ) rates, which calculated with the Kaplan-Meier method. Results : The overall loss to follow-up rate was 14.0% ( 12/161 ). The Overall survival (OS)rates at 1,2, and 3 years of TCM patients were 91.5%,84.8% and 84.8%. The Overall survival ( OS )rates at 1,2 and 3 years of TACE group patients were 91%, 85.5%, 60.5%. There was significant difference in survival time between the two groups ( P=0.008 ). The overall median survival time in TCM combined with interventional therapy ( TCM-IT )was 30.667 months and simple operation ( SO ) group was 29.267 months. The Disease free survival ( DFS )rates at 1,2 years of TCMO patients were 84.5% and 81.7%. The DFS rates at 1,2 years of ITO patients were 83.9% and 76.5%. There was no significantdifference in survival time between the two groups ( P=0.461 ). Conclusions : In comparison with TACE therapy, the comprehensive individualized treatment program using TCM for small hepatocellular carcinoma after resection may improve overall survival for small- HCC after resection. However, these findings need to be confirmed in a prospective, randomized controlled trial.
出处
《辽宁中医药大学学报》
CAS
2014年第12期63-66,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
中国博士后科学基金面上项目(2012M521937)
江苏省博士后科研资助计划项目(1201024C)
江苏省"333"工程课题(BRA2012232)
南京军区南京总医院疗养区科研课题(2013075)
关键词
原发性肝癌
介入治疗
中医药
回顾性队列研究
hepatocellular carcinoma
interventional therapy
herbal therapy
traditional Chinese medicine
retrospective cohort study