多重耐药菌株种类和危险因素相关性研究

Clinical Study on the Relationship Between the Species of Multi Drug Resistant Organisms and Risk Factors

目的探讨多重耐药菌(Multi drug resistant organisms,MDRO)的分布特点、抗菌药物的敏感性、菌株种类与危险因素的相关性。方法回顾性分析2012年10月1日—2013年6月30日159例MDRO感染患者的临床资料,分析MDRO的分布特点、抗菌药物的敏感性,MDRO种类与危险因素的相关性。结果 MDRO主要分布在下呼吸道;主要细菌依次为鲍曼不动杆菌、肺炎克雷伯菌、大肠埃希菌、金黄色葡萄球菌、铜绿假单胞菌。碳氢霉烯类抗生素的应用容易引起多重耐药的鲍曼不动杆菌和金黄色葡萄球菌感染。气管插管和气管切开更易发生多种MDRO感染。结论 MDRO呈现不同的耐药性和难治性;碳氢霉烯类抗生素的应用容易引起多重耐药的鲍曼不动杆菌和金黄色葡萄球菌感染。气管插管和气管切开是发生多种MDRO感染的危险因素。

Objective To investigate the distribution characteristics, antibiotic susceptibility, correlation between the strains and risk factors of multi drug resistant organisms （MDRO）. Methods We retrospectively surveyed the clinical data of 159 patients suffered MDRO infection and analyzing the distribution characteristics, antibiotic susceptibility, correlation between the strains and risk factors of MDRO. Results The MDRO were mainly distributed in the lower respiratory tract. The main bacteria were Acinetobaeter baumaunii （ Ab ） , Klebsiella pneumoniae （ Kpn ） , Escherichia eoli （ E. eoli ） , Staphylococcus aureus （SA） and Pseudomonas aeruginosa （PA）. Application of carbapenem antibiotics more easily caused infection of multidrug-resistant Acinetobacter baumannii and Staphylococcus aureus. Multiple MDRO infection was related to endotracheal intubation and tracheotomy. Conclusion MDRO presents different resistance and refractory. Application of carbapenem antibiotics more easily causes infection of multidrug-resistant Acinetobacter baumannii and Staphylococcus aureus. Endotracheal intubation and tracheotomy is risk factor of Multiple MDRO infection.