右美沙芬联合孟鲁司特治疗感染后咳嗽的临床效果观察

clinical effect observation of dextromethorphan combined with montelukast in treatment of cough after infection

目的 探讨右美沙芬联合孟鲁司特治疗感染后咳嗽的临床效果.方法 将感染后咳嗽患儿66例随机分为观察组和对照组,每组33例.观察组口服右美沙芬2.5～5.0 ml/次,2次/d;孟鲁司特钠片4nmg,1次/d.对照组口服不含右美沙芬的止咳化痰药,孟鲁司特钠片4 mg,用量与观察组一致.疗程均为2周.于治疗后第6、14天随访观察两组的治疗效果,进行各项指标评分.结果 治疗后第6天,观察组咳嗽评分为（2.28±0.71）分,低于对照组的（3.81±0.77）分,差异有统计学意义（P＜0.01）;治疗后第14天,观察组咳嗽评分为（1.26±0.38）分,低于对照组的（1.92±0.40）分,差异有统计学意义（P＜0.05）.结论 右美沙芬联合孟鲁司特对感染后咳嗽的治疗见效更快,服药依从性更好.

Objective To observe the clinical efficacy of dextromethorphan combined with montelukast in the treatment of post-infectious cough. Methods 66 children with post-infectious cough were selected and randomly divided into ob- servation group and control group,each group for 33 cases.The observation group was treated with dextromethorphan for 2.5-5.0 ml/time and 2 times a day,montelukast 4 mg and one time a day.The control group was treated with cough sup- pressant of dextromethorphan,montelukast 4 mg,and the dosage was the same with that of the observation group.Two weeks were a treatment course.The treatment effect of two groups was followed up 6 days and 14 days after treatment. The indicators were evaluated. Results For the sixth day after treatment,the score of the observation group was （2.28± 0.71） scores,was lower than （3.81±0.77） scores of the control group,the difference was significant （P〈0.01）.For the fourteenth day after treatment,the score of the observation group was （1.26±0.38） scores,was lower than （1.92±0.40） scores of the control group,the difference was significant （P〈0.05）. Conclusion Dextromethorphan combined with montelukast in treating post-infectious cough has rapid effect and good medication compliance.