尿激酶不同应用方法治疗心肌梗死的效果对比

The effect of urokinase different application methods for treatment of myocardial infarction

目的探讨尿激酶不同应用方法治疗心肌梗死的效果。方法将64例心肌梗死患者按照随机数字表法分为治疗组与对照组各32例,在常规治疗基础上,治疗组给予尿激酶静脉滴注治疗,对照组给予尿激酶静脉注射治疗。比较两组的临床疗效,所有患者治疗后随访3个月,观察相关并发症发生情况。结果治疗后治疗组与对照组的总有效率分别为96.9%和78.1%,治疗组的总有效率明显高于对照组(P<0.05)。治疗前两组血浆C-反应蛋白(CRP)差异无统计学意义(P>0.05),治疗后治疗组的血浆CRP值明显低于对照组,差异有统计学意义(P<0.05)。治疗后随访3个月,治疗组的再梗死、心源性休克、心力衰竭等并发症发生率明显低于对照组(P<0.05)。结论尿激酶采用静脉滴注治疗心肌梗死能更加有效地发挥治疗效果,缓解炎症反应,减少并发症,值得推广应用。

Objective To explore the effect of urokinase different application methods for treatment of myocardial in- farction. Methods 64 patients with myocardial infarction were equally divided into treatment group and control group based on the random number table,32 cases in each group,on the basis of conventional therapy,the treatment group were taken with intravenous infusion of urokinase therapy,the control group were taken with intravenous urokinase therapy. The clinical efficacy of two groups was compared,all patients were followed up for 3 months after treatment,the compli- cations were observed. Results After treatment,the total effective rate of treatment group and control group was 96.9% and 78.1% respectively,that of the treatment group was higher than that of the control group （P〈0.05）.Before treatment, the plasma CRP value of the two groups showed no significant difference （P〉0.OS）;After treatment,the plasma CRP level in the treatment group was lower than that of the control group,the difference was significant （P〈0.05）.All patients were followed up for 3 months after treatment,the overall incidence of complications of re-infarction,cardiogenic shock,heart failure in the treatment group was lower than that of the control group （P〈0.05）. Conclusion The use of intravenous in- fusion of urokinase treatment of myocardial infarction can play more effective treatment,it can alleviate inflammation,re- duce complications that should be widely applied in clinic.