摘要
总结脑缺血和再灌注损伤的发生和防治机制的研究进展,展望未来研究趋势。采用文献归纳总结的方法进行分析。脑缺血和再灌注造成的损伤与炎性反应、细胞内Ca2+超载、自由基的迅速增加、兴奋性氨基酸的大量释放等因素有关。防治脑缺血和再灌注损伤的机制主要有缩短缺血时间、阻断谷氨酸受体偶联的Na+和Ca2+内流、清除自由基、抑制凋亡、减轻炎症反应、促进神经元生长与修复等多个方面。多靶点联合治疗可能是防治脑缺血和再灌注损伤的一个方向。
To summarize the advances in mechanisms of damage and treatments of cerebral ischemia and reperfusion and fore -casts future research directions .The existing achievements in literatures were summarized .Cerebral ischemia and reperfusion damage were related to inflammatory response , intracellular calcium overload , free radicals injury , release of excitatory amino acids and other factors.The treatments included reducing ischemia time , blocking glutamate receptors , free radical scavenging , inhibition of apoptosis , reducing inflammation , and promoting neuronal growth , etc.Multi-target treatment would be future directions in treatment of cerebral ischemia.
出处
《药学实践杂志》
CAS
2014年第6期401-404,447,共5页
Journal of Pharmaceutical Practice
基金
国家科技部重大专项资助项目(2008ZXJ09014-010)
甘肃省省自然科学研究基金计划项目(1107RJZA100)
全军医药卫生科研基金课题(CLZ11JA06)
关键词
脑缺血
再灌注损伤
防治
损伤机制
cerebral ischemia
reperfusion damage
prevention and treatment
mechanism of damage
