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丙型肝炎病毒结构蛋白与非结构蛋白的研究进展 被引量：3

Research Progress in Structural and Nonstructural Proteins of Hepatitis C Virus
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摘要 丙型肝炎病毒(HCV)结构蛋白包括核心蛋白和2个包膜糖蛋白,即包膜糖蛋白E1和包膜糖蛋白E2;非结构蛋白包括NS1、NS2、NS3、NS4A、NS4B、NS5A和NS5B。结构蛋白主要在病毒颗粒侵入与组装中发挥作用。非结构蛋白与感染细胞蛋白相互作用,在病毒的复制以及病毒致病过程起关键作用。 Hepatitis C virus（HCV）structural protein is composed of core protein and two en-velope glycoproteins E1 and E2.The nonstructural proteins consist of NS2,NS3,NS4A,NS4B, NS5A and NS5B.Structural proteins are involved in the entry and assembly of viral particles.The nonstructural proteins interact with cellular proteins and participate in viral replication and patho-genesis.
作者 夏方娜 谢龙金 潘小玲 邹淑慧 刘金辉
机构地区 南昌大学基础医学院微生物学教研室 南昌大学第四附属医院输血科 南昌大学期刊社
出处 《南昌大学学报（医学版）》 CAS 2014年第10期93-97,共5页 Journal of Nanchang University：Medical Sciences
关键词 丙型肝炎病毒 结构蛋白 非结构蛋白 丙型肝炎病毒复制 hepatitis C virus structural proteins nonstructural proteins hepatitis C virus replication
分类号 R373.2 [医药卫生—病原生物学] Q51 [生物学—生物化学]
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参考文献39

  • 1Raja N S.Janjua K A. Epidemiology of hepatitis C virus infec-tion in Pakistan[J]. J Microbiol Immunol Infect,2008,41(1):4-8.
  • 2Gawlik K,Baugh J,Chatterji U,et al. HCV core residues criti-cal for infectivity are also involved in core-NS5A complex for-mation[J], PLoS One,2014,9(2) :e88866.
  • 3Liu J, Ding X,Tang J,et al. Enhancement of canonical Wnt/^-catenin signaling activity by HCV core protein promotes cellgrowth of hepatocellular carcinoma ceilsQ], PLoS One,2011,6(ll):e27496.
  • 4Goffard A,Callens N.Bartosch B,et al. Role of N-linked glycans inthe functions of hepatitis C virus envelope giycoproteins[J]. J Vir-ol,2005,79(13) :8400-8409.
  • 5Scarselli E* Ansuini H * Cerino R,et al. The human scavengerreceptor class B type I is a novel candidate receptor for thehepatitis C virus[J]. EMBO J,2002,21( 19) :5017-5025.
  • 6Mazumdar B,Banerjee A,Meyer K,et al. Hepatitis C virus Elenvelope glycoprotein interacts with apolipoproteins in facilita-ting entry into hepatocytes[J]. Hepatology,2011,54(4) s 1149-1156.
  • 7Boulestin A,Sandres Saune K,Payen J L,et al. Genetic hetero-geneity of the envelope 2 gene and eradication of hepatitis C vi-rus after a second course of interferon-alpha[J]. J Med Virol,2002,68(2):221-228.
  • 8Gan S W, Surya W. Vararattanavech A, et al. Two differentconformations in hepatitis C virus p7 protein account for pro-ton transport and dye release [J]. PLoS One, 2014 . 9(1):e78494.
  • 9Steinmann E,Doerrbecker J, Friesland M, et al. Characteriza-tion of hepatitis C virus intra- and intergenotypic chimeras re-veals a role of the glycoproteins in virus envelopment [J ]. JVirol,2013,87(24);13297-13306.
  • 10Gorzin Z.Gorzin A A.Tabarraei A,et al. Immunogenicity e-valuation of a DNA vaccine expressing the hepatitis C virusnon-structural protein 2 gene in C57BL/6 mice[J]. Iran Bi-omedj,2014,18(1);1-..

二级参考文献27

  • 1Ghany M G, Strader D B,Thomas D L, et al. American Associ- ation for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C:an update[J]. Hepatology, 2009, 49(4) :1335-1374.
  • 2Ghany M G,Nelson D R,Strader D B,et al. American Associ- ation for Study of Liver Diseases. An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases[J]. Hepatology, 2011,54 (4) : 1433-1444.
  • 3European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatitis C virus infeeti- on[J]. J Hepatol,2011,55(2) :245-264.
  • 4Afdhal N H,Mc Hutchison J G,Zeuzem S,et al. Hepatitis C pharmacogenetics:state of the art in 2010 [J].Hepatology,2011,53(1) :336-345.
  • 5Tillmann H L,Thompson A J,Patel K,et al. A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice[J]. Gastroenterology, 2010,139 (5) : 1586-1592.
  • 6Liao X W,Ling Y,Li X H,et al. Association of genetic varia- tion in IL28B with hepatitis C treatment-induced viral clear- ance in the Chinese Han population[J]. Antivir Ther, 2011,16 (2) :141-147.
  • 7Ruiz Extremera A,Munoz Gdmez J A,Salmer6n Ruiz M A, et a]. Genetic variation in interleukin 28B with respect to vertical transmission of hepatitis C virus and spontaneous clearance in HCV-infected children [J]. Hepatology, 2011, 53 ( 3 ) : 1830- 1838.
  • 8Legrand Ahravanel F, Colson P, Leguillou Guillemette L, et al. Influence of the HCV subtype on the virological response to pegylated interferon and ribavirin therapy[J].J Med Virol, 2009,81(12) :2029-2035.
  • 9Cheng W S,Roberts S K,Mc Caughan G. Low virological re- sponse and high relapse rates in hepatitis C genotype 1 pa- tients with advanced fibrosis despite adequate therapeutic do- sing[J]. J Hepatol, 2010,53 ( 11 ) : 616-623.
  • 10Fried M W, Hadziyannis S J, Shiffman M L, et al. Rapid viro- logical response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection[J]. J Hepatol,2011,55(6) :69-75.

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南昌大学学报（医学版）
2014年 第10期

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