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去甲万古霉素键合手性固定相的制备及应用

Synthesis of Polymer-bonded Norvancomycin Chiral Stationary Phase and its Application
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摘要 以去甲万古霉素为手性选择剂,采用4,4-二苯基甲烷异氰酸酯作为间隔臂,将其键合到氨化的单分散交联聚甲基丙烯酸环氧丙酯微球上,合成了去甲万古霉素手性固定相。该键合固定相在极性有机相模式下,成功地实现了五种手性药物对映体的分离,详细考察了流动相组成、酸碱添加剂用量、温度和流速等对药物对映异构的拆分影响,并初步探讨了其手性识别机理。 An antibiotic named norvancomycin was used as a new chiral selector, with 4,4-two phenyl methane diisocyanate as spacer arm to synthesis on the monodisperse poly ( glycidylmethacrylate-co-ethylenedimethacrylate ) beads for the preparation of norvancomycin-bonded chiral stationary phase ( NVC-CSP ) . The possible mechanisms of chiral discrimination were also discussed based on the enantioseparation of versatile structures of chiral compounds under different chromatographic modes. The mechanism of chiral separation was preliminarily studied.
出处 《广州化工》 CAS 2014年第22期105-107,161,共4页 GuangZhou Chemical Industry
关键词 单分散聚甲基丙烯酸环氧丙酯树脂 去甲万古霉素手性固定相 高效液相色谱 手性分离 monodisperse poly (glycidylmethacrylate-co-ethylenedimethacrylate) beads NVC-CSP high performance liquid chromatography chiral separation
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参考文献10

  • 1D'Acquarica I. New synthetic strategies for the preparation of no-vel chiral stationary phases for high performance liquid chroma-tography containing natural pool selectors [ J ]. Pharm. Biomed. Anal. , 2000, 23:3-11.
  • 2丁国生,刘莺,丛润滋,王俊德.去甲万古霉素键合手性固定相拆分β-受体阻滞剂类药物及其结构类似物的研究[J].色谱,2004,22(4):386-389. 被引量:15
  • 3丁国生,丛润滋,王俊德.去甲万古霉素键合手性固定相在反相条件下拆分氨基酸类衍生物[J].分析化学,2004,32(5):606-610. 被引量:9
  • 4Ding G S, Huang X J, Liu Y, et al. Ligand-Exchange Chromatographic Separation of eL_Amino Acids on Silica-bonded Chiral Stationary Phase [J]. Chromatographia, 2004,59 :443-454.
  • 5D'Acquarica I, Gasparrini F, Misiti D, et al. HPLC chiral stationary phases containing macrocyclicantibiotics : practical aspects and recognition mechanism [ J ]. Chromatogr. A, 1999, 857 : 145-155.
  • 6Tesarova E, Zaruba K, Flieger M. Enantioseparation of Semisynthetic Ergo Alkaloids on Vancomycin and Teicoplanin Stationary Phases [ J ]. Chromatogr. A,1999, 844:137-147.
  • 7Jandera P, Skavrada M, Klemmova K, et al. Effect of the mobile phase on the retention behaviour of optical isomers of carboxylic acids and amino acids in liquid chromatography on bonded Teicoplanin columns [ J]. Chromatogr. A, 2001,917 : 123-153.
  • 8Petritis K, Valleix A, Elfakir C, et al. Simultaneous Analysis of Underivatized Chiral Amino Acids by Liquid Chromatography -Ionspray Tandem Mass Spectrometry Using a Teicoplanin Chiral Stationary Phase [J]. Chromatogr. A, 2001, 913:331-340.
  • 9Aboul-Enein H Y, Ali I. HPLC enantiomeric resolution of novel aromatase inhibitors on cellulose and amylose based reversed and chiral stationary phases under reversed phase mode [J]. Chromatographia, 2000,52:679-691.
  • 10Karlsson C, Wikstrom H, Armstrong D W, et al. Enantioselective reversed-phase and non-aqueous capillary electrochromatography using a teicoplanin chiral stationary phase [ J]. Chromatogr. A, 2000,897: 349-363.

二级参考文献24

  • 1Da Shilu(达世禄),Xu Wei(徐伟),Dong Yaqiong(董亚琼).Chemistry(化学通报),1997,(2):33-44
  • 2Shao Baohai(邵保海),Xu Xiuzhu(徐秀珠),Lü Jiande(吕建德),Fu Xiaoyun(傅小芸).Chinese J.Analytical Chemistry(分析化学),2003,31(2):239-244
  • 3Guo Huijuan(郭惠娟),Han Xiaoqian(韩小茜),Liu Chunhui(柳春辉),Li Yongmin(李永民),Chen Liren(陈立仁).Chinese J.Anal.Chem.(分析化学),2003,31(8):901-905
  • 4Armstrong D W,Tang Y B,Chen S S.Anal.Chem.,1994,66(9):1473-1484
  • 5Ding Guosheng(丁国生),Huang Xiaojia(黄晓佳),Liu Xueliang(刘学良),Wang Junde(王俊德).Chinese J.Chromatogr.(色谱),2002,20(6):519-525
  • 6Editorial Committee of the Pharmacopoeia of the People's Republic of China(中华人民共和国药典委员会).The of Pharmacopoeia of P.R.China,Part Ⅱ(中华人民共和国药典,(二部)).Beijing(北京):Chemical Industry Press(化学工业出版
  • 7D'Acquarica I.J.Pharmaceut.Biomed.,2003,23:3-13
  • 8Peyrin E,Ravelet C,Nicolle D,Villet A,Grosset C,Ravel A,Vsary J.J.Chromatogr.A,2001,923:37-43
  • 9Gasper M P,Berthod A,Nair U B,Armstrong D W.Anal.Chem.,1996,68:2501-2514
  • 10Dalgliesh C E.J.Chem.Soc.,1952,47:3940-3942

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