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化疗药物的时辰药理学研究进展 被引量：5

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摘要 生物节律性（biological rhythms）是指机体内部从分子细胞,器官以及行为的各种水平的生命活动均按照一定的时间顺序进行有规律地循环往复周期性运动.从简单的单细胞生物到复杂的哺乳动物都存在生物节律性,它通过协调机体的生理、生化和代谢过程适应外部环境的变化.在哺乳动物中,生物钟的调节中枢位于下丘脑前部的视交叉上核（SCN）,生物钟通过眼睛的特殊光感受器感受昼夜光强度的变化,再通过视网膜到SCN的视网膜-下丘脑通路的信号转导,来引导生物节律性的产生,进一步影响体内的神经递质、内分泌和激素的分泌,控制和调节生物节律性.时辰药理学是研究药物作用与机体昼夜节律相互关系的一门学科.
作者 赵晓明 张彬 李道堂
机构地区 济南大学山东省医学科学学院医学与生命科学院 中国医学科学院
出处 《实用医药杂志》 2014年第11期1048-1049,共2页 Practical Journal of Medicine & Pharmacy
关键词 时辰化疗 生物节律性 肿瘤细胞 钟控基因 分子靶向治疗
分类号 R979.1 [医药卫生—药品]
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参考文献21

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二级参考文献43

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共引文献5

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二级引证文献33

实用医药杂志
2014年 第11期

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