肾茶对大鼠C-BSA慢性肾炎模型治疗作用的实验研究

Experimental Study on the Therapeutic Effect of Clerodendranthus Spicatus on C-BSA Chronic Glomerulonephritis of Model Rats

目的:研究肾茶对大鼠C-BSA慢性肾炎的治疗作用。方法:用天然牛血清蛋白(C-BSA)制备大鼠肾炎模型,以雷公藤多苷片作对照药物,观察肾茶(水提取和50%乙醇提取物)对大鼠肾炎模型24h尿蛋白及血清肌酐、尿素氮的影响,并制作肾脏病理切片,经HE染色后在光镜下观察其病理形态。结果:肾茶能明显降低C-BSA肾炎模型大鼠的尿蛋白、血清肌酐、尿素氮水平(P<0.05或P<0.01),光镜下观察发现给药组肾脏病变形态明显减轻。结论:肾茶对大鼠C-BSA肾炎模型具有良好的治疗作用,有望成为治疗慢性肾炎的候选植物药。

Objective：To study the therapeutic effect of clerodendranthus spicatus on C-BSA chronic nephritis of rats.Methods：Use natural bovine serum albumin （C-BSA） for the preparation of model rats with nephritis,tripterygium glycosides tablet as control medicine,observe effects of clerodendranthus spicatus （water extract and 50％ ethanol extract） on nephritis model rats in the aspects of urine protein and serum creatinine,urea nitrogen in 24 hours and produced renal biopsy,observe the pathological morphology under light microscope after HE staining.Results：Clerodendranthus spicatus could significantly decrease urinary protein,serum creatinine and urea nitrogen of C-BSA nephritis rats（P ＜ 0.05 or P ＜ 0.01）.Pathological features of renal lesion in the medicine group were significantly reduced under light microscopy observation.Conclusion：Clerodendranthus spicatuson has good therapeutic effects on C-BSA nephritis model rats,and it is expected to become a candidate plant medicine for the treatment of chronic nephritis.