痰热清注射液治疗手足口病临床观察

Clinical Observation of Tanreqing Injection in the Treatment of Hand-foot and Mouth Disease

目的:观察痰热清注射液治疗小儿手足口病临床疗效。方法:将符合纳入标准的104例小儿手足口病患儿随机分成治疗组与对照组,各52例。治疗组应用痰热清注射液[0.3~0.5ml/(Kg·d)],最高剂量不超过20ml,加入5%葡萄糖注射液100ml^200ml静脉滴注,每日1次,疗程7天左右。对照组应用单磷酸阿糖腺苷注射剂。观察两组患儿退热时间、退疹时间、疗程时限及临床疗效。结果:治疗组在退热时间、退疹时间、疗程时间上均优于对照组,两组差异具有统计学意义(P<0.05);总有效率治疗组高于对照组,两组比较有显著性差异(χ2=5.96,P<0.05)。两组患儿均未发生不良反应。结论:痰热清注射液治疗小儿手足口病临床疗效确切,副反应少,安全性高。

Objective：To observe the clinical efficacy of Tanreqing injection on treating hand-foot and mouth disease（HFMD）.Methods：104 cases of children with HFMD were divided into two groups at random：52 cases in the treatment group and 52 cases in the control group.The treatment group was given intravenous Tanreqing injection 0.3 ～0.5ml/（kg · d）which was added to 100 ～ 200ml of 5% glucose injection,one time per day for 7 days and the highest dose did not exceed 20ml a day.The control group was treated with monphosphory vidarabine injection.Observe two groups according to defervescence time,rash back time,duration of treatment and disease curative effect.Results：In the treatment group the defervescence time,return time and treatment time were less than those in the control group,and there was a significant difference （P 〈 0.05） ; total efficacy of treatment group was higher than that in the control group,and there was a significant difference （x^2 =5.96,P 〈 0.05）.No adverse reactions happened.Conclusion：Tanreqing injection is effective for the treatment of HFMD,with few side effects and higher safety.