中西医结合治疗中风后癫痫临床疗效的meta分析

Meta analysis of clinical efficacy of epilepsy after stroke treated with combination of traditional Chinese and Western medicine

目的：评价中西医结合治疗中风后癫痫的疗效。方法检索中国期刊全文数据库（CNKI）、中文科技期刊数据库（VIP）、中国学术期刊数据库（万方数据）、PubMed数据库中有关中西医结合治疗中风后癫痫的临床研究文献，筛选出中西医结合与西药对比治疗中风后癫痫的随机对照试验，采用RevMan 5软件进行统计分析。结果有7篇文献纳入研究，各研究间存在同质性（P＞0.05），采用固定效应模型进行meta分析，合并后OR＝5.17，95%CI（3.02，8.82），整体效应检验Z＝6.01，P＜0.01，治疗组与对照组疗效比较，差异有统计学意义，可认为中西医结合治疗中风后癫痫的总体效果优于对照组；倒漏斗图的图形显示不对称，表明文献存在发表偏倚。结论中西医结合治疗中风后癫痫的疗效优于单纯西药治疗，但由于文献存在发表偏倚，需要更多高质量大样本的临床研究进行证明。

Objective To evaluate clinical effects of integrated traditional Chinese and western medicine therapy for epilepsy after stroke. Methods Literatures about the treatment of epilepsy after stroke with the combination of traditional Chinese medicine and western medicine which come from the database such as CNKI, VIP, WanFang and Pubmed, were studied and all the randomized controlled trials on comparing therapeutic effects of treating epilepsy between combined treatment of TCM and western medicine and western medicine were enrolled. The Cochrane Collaboration＇s software RevMan 5 was used for meta-analysis. Results 7 articles were included in the study, there is homogeneity among these articles（P〉0.05）, The fixed effect model was used for the meta analysis. the combined results were OR=5.17, 95%CI（3.02, 8.82）, the overall effect of test Z=6.01, P〈0.01, the difference between the treatment group and the control groups was significant, that means the overall effect of the combination of traditional Chinese medicine and Western medicine treatment was better than western medicine treatment; Funnel plot graphic displayed asymmetrically, which indicated the literatures publication bias. Conclusion The current data indicate that the curative effect of TCM and west medicine combined treatment is better than pure western medicine therapy for epilepsy after stroke, but as the literature publication bias, clinical studies need more high quality large samples to prove this conclusion.