期刊文献+

抗病毒口服液联合利巴韦林气雾剂治疗手足口病的临床研究 被引量:11

Therapeutic effect of Kangbingdu oral liquid in combination with ribavirin aerosol for hand, foot, and mouth disease
原文传递
导出
摘要 目的:观察抗病毒口服液联合利巴韦林雾剂治疗手足口病的临床疗效。方法收集2012年5月至2014年1月河北省临西县人民医院儿内科手足口病患儿135例,按随机数字表法将患儿随机分为两组,对照组67例采用利巴韦林气雾剂治疗,治疗组68例在对照组治疗基础上配合口服抗病毒口服液治疗,治疗7d 后观察两组患儿临床症状的改善情况,并进行病毒检测。结果治疗组体温恢复时间[(2.51±0.42)d比(3.92±0.61)d;t=15.621,P<0.01]以及口腔溃疡[(3.01±0.32)d比(4.52±1.21)d;t=9.880, P<0.01]、皮疹消退[(4.22±1.34)d 比(6.33±1.41)d;t=8.914,P<0.01]时间均显著性短于对照组。治疗组痊愈率显著性高于对照组(88.2%比44.8%;χ^226.761,P<0.01),但总有效率与对照组无显著性差异(94.1%比83.6%;χ^22.801,P=0.094)。治疗组通用型肠道病毒(90.9%比52.6%;χ^213.331,P<0.01)和肠道病毒71型(83.3%比52.4%;χ^24.307,P=0.038)转阴率显著性高于对照组,但柯萨奇病毒A16型转阴率与对照组无显著性差异(93.3%比81.8%;χ^20.082,P=0.774)。结论利巴韦林气雾剂联合抗病毒口服液治疗可提高手足口病患儿的肠道病毒转阴率,缩短口腔溃疡和皮疹消退时间。 Objective To evaluate the therapeutic effect of Kangbingdu oral liquid in combination with ribavirin aerosol for hand, foot, and mouth disease (HFMD). Methods A total of 135 HFMD children were enrolled and assigned to receive ribavirin aerosol alone (ontrol group, 67 patients) or ribavirin aerosol plus Kangbingdu oral liquid group (treatment group, 68 patients) for 7 days. Therapeutic effect was evaluated as the time to fever resolution, subsidence of skin rash and oral ulcers. All throat swab samples were tested using a fluorescence quantitative RT-PCR assay for panenteroviruses, enterovirus 71(EV71)and Coxsackievirus A16 (CA16). Results The time to fever resolution(2.51±0.42 d vs. 3.92±0.61 d;t=15.621, P<0.01), subsidence of skin rash(4.22±1.34 d vs. 6.33±1.41 d;t=8.914, P<0.01)and oral ulcers(3.01±0.32 d vs. 4.52±1.21 d;t=9.880, P<0.01)in the treatment group were significantly shorter than those in the control group. The healing rate in the treatment group were significantly higher than that in the control group(88.2%vs. 44.8%;χ^226.761, P<0.01), and total effective rate was no different in treatment and control groups(94.1%vs. 83.6%;χ^22.801, P=0.094). The rates of conversion from positive to negative for panenteroviruses(90.9% vs. 52.6%;χ^213.331, P<0.01)and EV71(83.3%vs. 52.4%;χ^24.307, P=0.038)in the treatment group were significantly higher than those in the control group, and the rate of conversion from positive to negative for CA16 was no different in treatment and control groups(93.3%vs. 81.8%;χ^20.082, P=0.774). Conclusion Kangbingdu oral liquid in combination with ribavirin aerosol may improve the rate of conversion from positive to negative for enteroviruses, reduced the time to fever resolution, subsidence of skin rash and oral ulcers in HFMD children.
作者 叶秀春
出处 《国际中医中药杂志》 2014年第12期1089-1091,共3页 International Journal of Traditional Chinese Medicine
关键词 手足口病 利巴韦林 抗病毒口服液 儿童 Hand,foot and mouth disease Ribavirin Kangbingdu oral liquid Child
  • 相关文献

参考文献9

  • 1Snell NJ. Ribavifin-current status of a broad spectrum antiviral agent[J].ExpertOpinPharmacother, 2001, 2 (8): 1317-1324.
  • 2Li ZH, Li CM, Ling P, et al. Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication[J]. J lnfectDis, 2008, 197 (6): 854-857.
  • 3Vijauaraghavan PM, Chandy S, Selvaraj K, et al. Virological investigation of hand, foot, and mouth disease in a tertiary care center in South India[J]. J Glob Infect Dis, 2012, 4 (3): 153-161.
  • 4贾蕾,向阳,张新,刘白薇,田丽丽,李爽,黄芳,王全意,黎新宇,庞星火.2010年北京市手足口病聚集性病例流行病学分析[J].国际病毒学杂志,2011,18(1):1-4. 被引量:67
  • 5Moriyama K, Suzuki T, Negishi K, ct al. Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNAviral activity[J]. J Med Chcm, 2008, 51 (1): 159-166.
  • 6赵应华.小儿手足口病4种联合用药方案的对比分析[J].中国药业,2012,21(9):33-34. 被引量:8
  • 7手足口病诊疗指南(2010版)[J].中国实用乡村医生杂志,2012,19(19):9-11. 被引量:133
  • 8伏瑾,张艳玲,孙春荣,刘燕燕,崔小岱,王天有.实时RT-PCR检测159例手足口病患儿样本中肠道病毒的结果分析[J].中华实验和临床病毒学杂志,2009,23(6):488-490. 被引量:16
  • 9中华人民共和国卫生部,教育部.关于进一步加强托幼机构和小学手足口病防控工作的通知[EB/OL].[2012-04-28]http://www.moh.gov.cn/publicfiles/business/htmlfiles/mohjbyfkzj/s3578/201204/54574.htm.

二级参考文献26

共引文献220

同被引文献104

引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部