中山市2011年健康儿童脊髓灰质炎、麻疹和乙型肝炎抗体水平监测

Monitoring and analysis of antibody levels of measles,poliomyelitis and Hepatitis B in 1-14 year-old children in Zhongshan city in 2011

目的了解中山市1～14岁健康儿童脊髓灰质炎（脊灰）病毒、麻疹病毒和乙型肝炎（乙肝）病毒抗体水平状况,为维持无脊灰、消除麻疹和控制乙肝提供依据。方法采用多阶段整群抽样方法,随机选择220名1～14岁健康儿童抽取静脉血,采用ELISA法检测麻疹病毒抗体Ig G、乙肝病毒表面抗原和抗体;用中和试验检测脊灰（Ⅰ、Ⅱ、Ⅲ）型病毒中和抗体。结果脊灰、麻疹和乙肝病毒抗体阳性率分别为91.36%、93.18%和66.36%,脊灰病毒Ⅰ、Ⅱ、Ⅲ型和麻疹病毒抗体几何平均滴度（GMT）分别为1∶215.90、1∶119.05、1∶31.40和1∶1 254.45;乙肝病毒表面抗原阳性率为1.36%。结论中山市1～14岁健康儿童对脊灰病毒具有较高的免疫水平,已形成对脊灰病毒有效的免疫屏障;乙肝得到有效控制;但麻疹未能形成有效的免疫屏障。

Objective To investigate status for poliomyelitis（ polio）, measles and Hepatitis B vaccination in children 1-14 year old in Zhongshan city. Methods 220 healthy children were selected by multi-stage cluster sampling method, and a- gainst polio, measles and hepatitis B antibody levels were detected by ELISA. Results Polio, measles and anti-hepatitis B antibodies positive rates were 91.36% ,93.18% and 66.36% respectiveiy. Ⅰ , Ⅱ ,Ⅲ type polio and measles antibodies geometric mean titer （GMT） were 1 ： 215.90,1 ： 119.05,1 ： 31.40, 1 ： 1 254.45 respectively; hepatitis B virus surface antigen （HBsAg） positive rate was 1.36%. Conclusion 1 - 14 year-old children in Zhongshan city have both high im- mune antibody responses for hepatitis B and poliomyelitis, but measles.