植入式遥测技术偶测血压方法探究

Measurement of casual blood pressure by implantable telemetry

目的：建立植入式遥测技术偶测血压方法,提高植入子使用寿命和效率。方法：以自发性高血压大鼠（SHR）为动物模型,采用植入式遥测仪记录SHR连续多天24 h血压等生理参数,分别以30 min、1 h和3 h为间隔时段,计算各时段的血压均值,观察血压均值动态变化的特征,并采用相似因子比较法,将各时段的血压均值与24 h血压均值进行比较和分析。结果：SHR在连续监测的24 h内,基础血压随时间一直在波动变化;经比较研究发现,在20：00-23：00时段内获取的血压均值与24 h血压均值较为相似,表现出较高的稳定性。进一步的药效学实验证明,在该时段内获取的血压均值曲线与24 h血压均值曲线相似,相似因子达到77.8。结论：植入式遥测仪测定SHR血压时,可选择在20：00-23：00时间段内开机,此时段内获取的血压均值稳定、重复性好,能代表24 h连续开机获取的血压均值。本研究是对目前植入式遥测技术连续开机测定血压方法的有力补充,对于提高植入子使用寿命和效率,开展长期药效学研究具有重要意义。

AIM： To establish a method of casual blood pressure measurement by implantable telemetry and to improve the efficiency of telemeter. METHODS： The spontaneously hypertensive rats（ SHR） were used as the experimental animal model,and the mean blood pressure（ MBP） of 24 h and other physiological parameters were recorded for consecutive days by implantable telemetry. The data of MBP at different intervals of 30 min,1 h and 3 h were calculated,and the dynamic change of the MBP was observed. The similarity of the MBP at different time intervals with the MBP of 24 h was compared by a similarity factor comparison method. RESULTS： The basic blood pressure of 24 h changed and fluctuated according to some rhythm. Interestingly,in the time period of 20： 00 - 23： 00,the MBP showed a high stability,and had a similarity to the MBP of 24 h. In further pharmacodynamic experiments,it was displayed that the MBP curve at this period was highly similar to the MBP curve of 24 h,and the similarity factor reached up to 77. 8. CONCLUSION： Based on the time period of 20： 00 - 23： 00,the method of casual blood pressuremeasurement by implantable telemetry demonstrates high accuracy,repeatability and typicality,suggesting that it could be a new alternative blood pressure measurement method for improving the battery life and efficiency of telemeter to carry out long-term pharmacodynamic study.