长期维持血液透析患者腰椎QCT骨密度定量检测结果分析

Analysis of bone mineral density of the lumbar vertebra in long-term dialysis patients using QCT

目的探讨长期维持性血液透析患者的骨质疏松症发病率,为临床诊断和治疗提供依据。方法整理在本院进行腰椎QCT骨密度测量中的透析患者45例,其中男25例、女20例,年龄25~77岁、平均56.1岁,透析时间20~134个月、平均56.3个月;随机选取健康人群45例,其中男17例、女28例,年龄30~78岁、平均49.2岁。按男女性别分为透析组与对照组。年龄、性别差异无统计学意义（P〉0.05）。利用SPSS19.0对数据进行处理,计量资料采用方式表示,采用配对样本T检验、独立样本T检验,P〈0.05表示差异有显著性;计数资料采用卡方检验。结果长期维持血液透析患者的腰椎骨密度要低于健康人群的骨密度（P〈0.05）;骨质疏松症发病率要高;骨密度改变与透析时间无统计学意义（P〉0.05）。结论长期维持血液透析患者的腰椎骨密度低于健康人群,骨质疏松症的发病率高。

Objective To investigate the incidence of osteoporosis in long-term maintenance dialysis patients, and to provide the basis for clinical diagnosis and treatment.Methods Data of bone mineral density of the lumbar vertebrae in QCT of 45 dialysis patients in our hospital were collected, including 25 males and 20 females, aging from 25 to 77 years old, and 56.1 years in average.The dialysis time was 20 to 134 months, with a mean of 56.3 months.Forty-five healthy people were randomly selected, including 17 males and 28 females, aging from 30 to 78 years old, and 49.2 years in average.According to the gender they were divided into dialysis group and control group.No statistical difference was found in age and gender （ P〉0.05 ） .SPSS19.0 was used to process the data.The measurement data were represented in, and evaluated using paired sample T test and independent sample T test.P〈0.05 was considered significant difference.Count data were evaluated using chi square test.Results Bone mineral density of the lumbar bone in long-term maintenance dialysis patients was lower than that in healthy people （ P〈0.05） .The incidence of osteoporosis was higher in these patients.No significance was found between bone mineral density and duration of dialysis （P〉0.05）.Conclusion The bone mineral density of the lumbar bone in long-term dialysis patients is lower than that in healthy people.The incidence of osteoporosis is high.