慢性软组织损害性疼痛外周不同组织中TNF-α表达的研究

Expression of TNF-α in peripheral tissue from chronic soft tissue lesion induced pain patients

目的研究慢性软组织损害性疼痛患者不同外周组织中TNF-α的表达,探讨其致痛机制。方法选择行手术治疗的软组织损害性疼痛患者18例作为实验组,腰椎间盘突出症患者16例为对照组,分别取腰部深筋膜、肌肉、骨表面软组织标本,检测各部位组织中TNF-α的表达并进行比较。结果实验组中肌肉组织TNF-α的表达最高,与深筋膜和骨表面组织相比有显著差异(P<0.05),与对照组相比有显著差异(P<0.05),对照组各组织中TNF-α表达相比无差异。结论TNF-α在慢性软组织损害性疼痛中可能起重要作用,肌肉组织是疼痛的主要病灶部位。

Objective To study the expression of TNF-α in peripheral tissue from chronic soft tissue lesion induced pain patients and to explore the underlying mechanisms. Methods 34 patients undergoing operation therapy were selected and divided into two groups：18 patients suffered from soft tissue lesion induced pain were assigned to experimental group,16 patients suffered from lumber lumbar disc heniation were assigned to the control group. The expression of TNF-α in soft tissues from lumbar deep fascia,lumbar muscle,and soft tissue from bone surface was assayed. Results The TNF-α level in lumbar muscle tissue from experiment group was highest compared with tissues from the lumbar deep fascia or tissues from the bone surface（P 〈0.05）,which was higher than that from the control group. In the control group,there were no significant differences among the three groups. Conclusion TNF-α may play an important role in chronic soft tissue lesion induced pain,lumbar muscle tissue is the major lesion location.