摘要
胃癌发病率占全球癌症发病率的第4位,死亡率占第2位。大多数胃癌患者就诊时已属中晚期,失去手术机会,化疗及分子靶向治疗作为胃癌治疗的有效手段,越来越受到临床研究及实践的重视。近年来,抗表皮生长因子受体(EGFR)家族靶向治疗在胃癌治疗中取得了丰硕的成果。本文总结了EGFR家族信号转导机制及相关靶向药物在胃癌治疗中的研究进展。
Incidence of gastric cancer accounted for the fourth in global cancer incidence, and the mortality accounted for the second. Most patients bearing gastric cancer are already advanced and unresectable at the time of diagnosis. Chemotherapy and molecu？lar targeted therapy have been more and more emphasised on clinical research and practice as an effective means of treatment of gastric cancer. In recent years, the targeted therapy of epidermal growth factor receptor（EGFR） family has achieved fruitful results in the treatment of gastric cancer. This article summarizes the signal transduction mechanisms of EGFR family and associated targeted drugs in the treatment of gastric cancer.
出处
《临床肿瘤学杂志》
CAS
2014年第11期1043-1047,共5页
Chinese Clinical Oncology
基金
国家青年科学基金资助项目(81101798)
