泌尿生殖系统无乳链球菌感染的临床病区分布及耐药性分析

Analysis of clinical distribution and drug resistance of streptococcus agalactiae from genitourinary tract

目的分析泌尿生殖系统无乳链球菌感染的临床病区分布及耐药情况,为临床提供治疗依据及合理的用药方案。方法对临床送检的阴道分泌物标本及中段尿标本进行常规培养,检出的无乳链球菌株经由VITEK-2全自动细菌鉴定分析仪进行鉴定和药敏分析。结果 1 563例送检标本发现57例患者有无乳链球菌感染,感染率为3.64%;无乳链球菌的临床病区分布以妇产科最高,其次是神经内科和肾病内科;药敏结果显示所有检出的无乳链球菌对四环素的耐药率高达77.2%,其次是红霉素为49.1%、克林霉素为42.1%、环丙沙星40.4%、左氧氟沙星36.8%。结论国内无乳链球菌的感染率较高,尤其是在妇产科病区,临床上应加强对无乳链球菌的培养检测,及时并合理应用抗菌药物,以降低耐药率。

Objective： To investigate clinical distribution and drug resistance of streptococcus agalactiae from genitoUrinary tract in order to provide a clinical guidance for treatment. Methods. The clinic samples from the genitourinary tract were cultured by routine method. The streptococcus agalactiae were identified by automatic VITEK-2 system and the drug sensitivity test was performed. Results： Fifty seven specimens were found to be infected with streptococcus agalactiae in 1 563 specimens. The infection rate was 3.64%. The most specimens infected by streptococcus agalactiae were from obstetrics ward,secondly from internal neurology and nephrology wards. The drug resistance rate of streptococcus agalactiae isolated to tetracycline, erythromycin, clindamycin, ciproflox and levofloxacin was 77.2%,49.1%,42.1%,40.4% and 36.8% respectively. Conclusions： The culture tests of streptococcus agalactiae should be strengthen especially for obstetrics ward. It is important to enforce the rational use of antibiotics to reduce the drug resistance.