难治性癫基因靶向治疗研究进展

Research progress of gene target therapy for refractory epilepsy

目前难治性癫的基因治疗策略主要通过调节神经递质网络、神经肽Y和神经营养因子等以发挥抗癫作用。其中研究较为热门的靶点包括γ-氨基丁酸及其受体、N-甲基-D-天冬氨酸及其受体、甘丙肽、神经肽Y和神经营养因子等。本文就上述靶点的主要研究结果、各研究的优劣做简要介绍,以为临床解决难治性癫提供证据。

Nowadays, the strategies of gene therapy for the treatment of refractory epilepsy （RE） mainly include modulating neurotransmitter systems, neuropeptide Y （NPY） and neurotrophic factors. Among them, the hot target spots include γ-aminobutyric acid （GABA） and its receptor, N-methyl-D- aspartate （NMDA） and its receptor, galanin, NPY and neurotrophic factors. This paper reviews the chief research results, and advantages and disadvantages of studies, and provides evidence for the treatment of refractory epilepsy.