NADPH氧化酶在电磁辐射生物效应中的作用

Mechanisms of NADPH Oxidase Biological Effects in The Electromagnetic Radiation

电磁辐射是一种复合电磁波,而人体生命活动包含一系列的生物电活动,这些生物电对环境的电磁波敏感,因此,电磁辐射可对人体造成危害.关于电磁辐射诱导的生物效应研究虽多,然而其具体机制尚不清楚.近年来,发现烟酰胺腺嘌呤二核苷酸磷酸氧化酶(NADPH氧化酶),又称呼吸爆发氧化酶(respiratory burst oxidase homologue,Rboh)在电磁辐射产生的生物学效应中扮演重要角色,电磁辐射可直接或间接活化NADPH氧化酶复合体,然后NADPH氧化酶可以将细胞内NADPH的电子转移而形成活性氧,或者通过一系列炎症因子和相关基质金属蛋白酶等参与炎症、防御以及组织修复等生命过程.本文对NADPH氧化酶在电磁生物学效应中的作用进行了综述.

Electromagnetic radiation is a kind of composite electromagnetic wave and human body contains a series of bioelectrical activities which are sensitive to the environmental electromagnetic wave. Therefore, the electromagnetic radiation may do harm to our human body. Although there are numbers of studies on biological effects induced by electromagnetic radiation, the mechanisms are still unclear. Recently, some researchers have revealed that nicotinamide adenine dinucleotide phosphate oxidase（NADPH oxidase, also known as the respiratory burst oxidase homologue） played an important role in biological effects induced by electromagnetic radiation. Electromagnetic radiation can activate NADPH oxidase complex in direct or indirect ways, then NADPH oxidase can transfer electrons of NADPH and the reactive oxygen species are formed or through some inflammatory factors, correlated matrix metalloproteinase in cells which may lead to inflammation, cell defense, tissue repair and the other processes of life. So, we review recent observations correlated with the mechanisms of it here.