自体富含血小板血浆凝胶治疗Ⅳ期褥疮探讨

Efficacy of platelet-rich plasma gel in the treatment of stage Ⅳ pressure ulcer

目的观察自体富含血小板血浆（platelet-rich plasma，PRP）凝胶在Ⅳ期褥疮创面中的作用。方法2012年12月至2013年12月我科共计12例Ⅳ期褥疮患者，取患者自身外周静脉血20ml，2次离心制作自体PRP，将其与凝血酶一钙剂按比例混合形成凝胶，放置于创面。每4d更换PRP凝胶，观察创面的愈合情况。结果所有Ⅳ期褥疮创面在2次换药感染得到控制并且肉芽组织新鲜。创面完全愈合平均8周，更换PRP敷料平均16次。治疗过程中无患者出现不良反应。结论PRP能够有效的控制褥疮创面的感染和促进创面的愈合。

Objective To observe the effects of platelet-rich plasma （PRP） gel in the treatment of Ⅳ stage pressure ulcers. Methods A total of 12 patients with stage Ⅳ pressure ulcers were treated with PRP gel from December 2012 to December 2013 in our department. The PRP gel was formed by autologous PRP mixed with thrombin and calcium chloride. The PRP gel was applied to the wound after dressing. Time intervals between dressing were 4 days. Overall pressure ulcer improvement was assessed every week until complete wound healing. Results All stage Ⅳ pressure ulcer wound infection was controlled and fresh granulation tissue was found after 2 times of PRP gel covering. The time of ulcer wound healing were 6-10 weeks （mean 8 weeks）. The times of changing the PRP gel were 16. No patients experienced adverse reactions during treatment. Conclusions PRP gel can effectively control the pressure ulcer infection and promote ulcer wound healing.