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远隔缺血预适应和后适应对缺血性卒中的脑保护作用及机制 被引量:11

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摘要 1 缺血性脑卒中的远隔缺血预适应与后适应 近年来,缺血性脑卒中发病率、致残率及病死率均较高,且易再发,严重威胁人类的健康.目前治疗缺血性卒中最有效的方法是溶栓治疗,但溶栓适应证、溶栓时机和溶栓风险均限制其使用,且溶栓后可能会发生再灌注损伤,加重神经损害.因此探究一种有效可行的治疗方法非常必要.虽然各种治疗方法不断进展,但根本的治疗措施是挽救缺血半暗带,使闭塞的血管再通,尽量恢复缺血脑组织的正常血供,防止缺血脑组织发生不可逆损伤.目前,医学家们致力于研究一种内源性的神经保护,即脑缺血耐受,远隔缺血适应由于不直接作用于靶组织,以避免对重要器官造成损伤,且动物实验显示出显著的神经保护作用而受到众多学者的关注.
作者 甄晓悦 陆晓
出处 《中国康复医学杂志》 CAS CSCD 北大核心 2014年第12期1200-1202,共3页 Chinese Journal of Rehabilitation Medicine
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