Wnt/β-catenin信号与胃癌防治研究进展

Research progress of Wnt/β-catenin signaling pathway in prevention and treatment of gastric cancer

胃癌的发生、发展机制复杂,细胞信号通路异常活化在其中起着至关重要的作用。Wnt/β-catenin信号参与胃癌细胞的增殖、侵袭和转移,并有效诱导胃癌的耐药和再生,是介导胃组织癌变的关键信号;靶向抑制Wnt/β-catenin能够抑制胃癌的生长、侵袭转移,增加化疗药物的敏感性。本文对Wnt/β-catenin在胃癌发生和发展中的作用和干扰Wnt/β-catenin治疗胃癌的最新研究进展进行综述,期望为胃癌的防治提供新的思路。

The mechanism underlying the occurrence and development of gastric cancer is complex. Abnormal activation of cell signaling pathways play a vital role in the occurrence and development of cancer. The Wnt/β-catenin signaling pathway participates in gastric cancer cell proliferation, invasion and metastasis and effectively induces drug resistance of the gastric cancer cells; it is also the key signal to mediate gastric carcinogenesis. Disturbances of Wnt/β-catenin signaling pathway can inhibit the growth, invasion and metastasis of gastric cancer and increase the sensitivity of the cancer cells to chemotherapeutic drugs. The authors reviewed the research progress of the role of Wnt/β-catenin signaling pathway in the occurrence and development of gastric cancer and discussed the prospective of preventing gastric cancer by interfering with Wnt/β-catenin signaling pathway.